Marchisio Mario Andrea
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Methods Mol Biol. 2012;813:3-21. doi: 10.1007/978-1-61779-412-4_1.
Computational synthetic biology has borrowed methods, concepts, and techniques from systems biology and electrical engineering. Features of tools for the analysis of biochemical networks and the design of electric circuits have been combined to develop new software, where Standard Biological Parts (physically stored at the MIT Registry) have a mathematical description, based on mass action or Hill kinetics, and can be assembled into genetic networks in a visual, "drag & drop" fashion. Recent tools provide the user with databases, simulation environments, formal languages, and even algorithms for circuit automatic design to refine and speed up gene network construction. Moreover, advances in automation of DNA assembly indicate that synthetic biology software soon will drive the wet-lab implementation of DNA sequences.
计算合成生物学借鉴了系统生物学和电气工程的方法、概念及技术。用于分析生化网络和设计电路的工具特性已被结合起来，以开发新软件，其中标准生物部件（实际存储于麻省理工学院登记处）具有基于质量作用或希尔动力学的数学描述，并能以可视化的“拖放”方式组装成基因网络。近期的工具为用户提供数据库、模拟环境、形式语言，甚至用于电路自动设计的算法，以优化和加速基因网络构建。此外，DNA组装自动化方面的进展表明，合成生物学软件很快将推动DNA序列在湿实验室的实施。
