Yang C B, Tang F K, Pan X Z
Fujian Institute of TCM, Fuzhou.
Zhong Xi Yi Jie He Za Zhi. 1990 Aug;10(8):458-60, 451.
161 cases of chronic gastritis (including 59 superficial gastritis, 86 atrophic gastritis, 16 superficial gastritis combined with atrophic gastritis) typed in deficiency syndrome (including 64 Spleen-deficiency syndrome, 97 Spleen-Kidney-deficiency syndrome) were studied clinically with modern medicinal multiple-index. The gastroscope image, pathologic changes of gastric mucosa, stomach barium meal examination, gastric acid, serum gastrin, urine pepsinogen, urine 17-ketosteroid, vegetative nerve function, peripheral blood picture, etc. were selected as observation indices. The preliminary findings showed that in Spleen-deficiency patients, the superficial gastritis constituted the majority, the asthenic stomach constituted the minority, the gastric secretion and the serum gastrin were on the high side, the urine pepsinogen, the adrenocortical function and the hemoglobin were on the low side, but the white blood cell was rather normal; otherwise, in Spleen-Kidney deficiency patients, the atrophic gastritis and the asthenic stomach constituted the majority, the gastric secretion decreased, the serum gastrin level was higher, while the urine pepsinogen, the adrenocortical function, white blood cell and the hemoglobin were on the low side. It was also found that in certain same inflammation changes, the gastric secretion of the Spleen-Kidney-deficiency syndrome was markedly than that of Spleen-deficiency syndrome. With the treatment method of invigorating the Spleen and reinforcing the Spleen-Kidney, each index was relatively improved. The degree of seriousness to inflammation changes of gastric mucosa and the disturbance or imbalance of gastric secretion function were reflected from the Spleen-deficiency and the Spleen-Kidney-deficiency syndromes of chronic gastritis. It is suggested that hemopoiesis and hypothalamo-adenohypophysial-adrenal cortical axis be influenced.
对161例慢性胃炎患者（包括59例浅表性胃炎、86例萎缩性胃炎、16例浅表性胃炎合并萎缩性胃炎）进行虚证分型（包括64例脾虚证、97例脾肾两虚证），采用现代医学多指标进行临床研究。选取胃镜图像、胃黏膜病理变化、胃钡餐检查、胃酸、血清胃泌素、尿胃蛋白酶原、尿17-酮类固醇、植物神经功能、外周血象等作为观察指标。初步研究结果显示，脾虚患者中，浅表性胃炎占多数，虚寒型胃占少数，胃分泌及血清胃泌素偏高，尿胃蛋白酶原、肾上腺皮质功能及血红蛋白偏低，但白细胞较为正常；而在脾肾两虚患者中，萎缩性胃炎及虚寒型胃占多数，胃分泌减少，血清胃泌素水平较高，同时尿胃蛋白酶原、肾上腺皮质功能、白细胞及血红蛋白偏低。还发现，在某些相同的炎症变化中，脾肾两虚证的胃分泌明显低于脾虚证。采用健脾及健脾补肾的治疗方法后，各项指标均有相对改善。慢性胃炎的脾虚证和脾肾两虚证反映了胃黏膜炎症变化的严重程度以及胃分泌功能的紊乱或失衡。提示造血功能及下丘脑-腺垂体-肾上腺皮质轴受到影响。
