基质金属蛋白酶-2、-8、-9 和 -13 在口腔舌癌中的预后意义。
Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer.
机构信息
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital, HUS and University of Helsinki, Helsinki, Finland.
出版信息
J Oral Pathol Med. 2012 May;41(5):394-9. doi: 10.1111/j.1600-0714.2011.01110.x. Epub 2011 Nov 16.
BACKGROUND
Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring.
METHODS
Seventy-three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992-2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)-2, -8, -9, and -13 was compared with patient characteristics and outcome.
RESULTS
Nuclear expression of MMP-13, but not cytoplasmic expression of MMP-2, -8, and -9, was associated with invasion depth (P = 0.017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042).
CONCLUSION
Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC.
背景
口腔舌鳞状细胞癌（OTSCC）常转移至颈部淋巴结。这种疾病进展的机制尚不完全清楚。我们旨在寻找新的预测标志物用于诊断和疾病监测。
方法
我们纳入了 1992-2002 年在芬兰赫尔辛基大学中心医院治疗的 73 例连续 T1N0M0 和 T2N0M0 OTSCC 患者。从原发性肿瘤制备组织微阵列块并进行免疫染色。比较基质金属蛋白酶（MMP）-2、-8、-9 和 -13 的免疫表达与患者特征和结局。
结果
MMP-13 的核表达，而不是 MMP-2、-8 和 -9 的细胞质表达，与浸润深度（P=0.017）和肿瘤大小（P=0.008）相关。此外，高核 MMP-13 表达预示不良结局（P=0.042）。
结论
我们的结果表明，MMP-13 尤其可能被视为 OTSCC 的预后生物标志物。
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