Department of Chemistry, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey.
J Enzyme Inhib Med Chem. 2013 Feb;28(1):72-7. doi: 10.3109/14756366.2011.631536. Epub 2011 Nov 15.
The methoxy substitued two novel bis triazole-schiff bases (6 a-b) were synthesized with 4-amino-3,5-diethyl-4H-1,2,4-triazole and various bis-aldehydes. Their amine derivatives prepared by reduced with NaBH(4) (5 a-b). The obtained products 6 a-b and 7 a-b were identified by FT-IR, (1)H-NMR, (13)C-NMR. The bis triazole-schiff bases and amine derivatives were tested for antimicrobial activity using the agar diffusion technique against 11 bacteria. The synthesized compounds (6 a-b and 7 a-b) were screened for their antielastase, antiurease and antioxidant activities. The resuts showed that the synthesized compounds (6 a-b and 7 a-b) had effective antielastase and antiurease activities.
甲氧取代的两个新型双三唑席夫碱（6a-b）是通过 4-氨基-3,5-二乙基-4H-1,2,4-三唑和各种双醛合成的。它们的胺衍生物是通过 NaBH(4)（5a-b）还原得到的。所得产物 6a-b 和 7a-b 通过 FT-IR、（1）H-NMR、（13）C-NMR 进行鉴定。采用琼脂扩散技术，对 11 种细菌进行了双三唑席夫碱和胺衍生物的抗菌活性测试。合成的化合物（6a-b 和 7a-b）被筛选其弹性蛋白酶、脲酶和抗氧化活性。结果表明，合成的化合物（6a-b 和 7a-b）具有有效的弹性蛋白酶和脲酶活性。
