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从吗啉和硫代吗啉出发合成新型席夫碱和唑-β-内酰胺衍生物,并研究它们的抗结核、抗脲酶活性、乙酰胆碱酯酶抑制作用和抗氧化能力。

Synthesis of novel Schiff bases and azol-β-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity.

机构信息

Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey.

Department of Chemistry and Chemical Processing Technology, Karadeniz Technical University, 61080 Trabzon, Turkey.

出版信息

Bioorg Chem. 2019 Jul;88:102928. doi: 10.1016/j.bioorg.2019.102928. Epub 2019 Apr 16.

Abstract

In this study, new Schiff bases and β-lactam derivatives containing morpholine and thio morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and antioxidant properties of all synthesized compounds were investigated and highly effective products were obtained. In this context, new effective structures were introduced to the literature.

摘要

在这项研究中,合成了含有吗啉和硫代吗啉核的新席夫碱和β-内酰胺衍生物。研究了所有合成化合物的抗菌、抗氧化、抗菌和抗氧化性能,并获得了高效的产物。在这方面,新的有效结构被引入文献。

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