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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

作者信息

Choi Won-Tak, Duggineni Srinivas, Xu Yan, Huang Ziwei, An Jing

机构信息

Department of Pathology, The University of Washington School of Medicine, Seattle, Washington 98195, United States.

出版信息

J Med Chem. 2012 Feb 9;55(3):977-94. doi: 10.1021/jm200568c. Epub 2011 Dec 2.

Abstract
摘要

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Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.
J Med Chem. 2011 Nov 10;54(21):7648-62. doi: 10.1021/jm2009716. Epub 2011 Oct 11.
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Agonists for the Chemokine Receptor CXCR4.
ACS Med Chem Lett. 2011 Aug 11;2(8):597-602. doi: 10.1021/ml200084n. Epub 2011 Jun 6.
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Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.
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Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.
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Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells.
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