Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
作者信息
Choi Won-Tak, Duggineni Srinivas, Xu Yan, Huang Ziwei, An Jing
机构信息
Department of Pathology, The University of Washington School of Medicine, Seattle, Washington 98195, United States.
出版信息
J Med Chem. 2012 Feb 9;55(3):977-94. doi: 10.1021/jm200568c. Epub 2011 Dec 2.
Abstract
摘要
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本文引用的文献
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J Med Chem. 2011 Nov 10;54(21):7648-62. doi: 10.1021/jm2009716. Epub 2011 Oct 11.
2
Agonists for the Chemokine Receptor CXCR4.趋化因子受体CXCR4的激动剂
ACS Med Chem Lett. 2011 Aug 11;2(8):597-602. doi: 10.1021/ml200084n. Epub 2011 Jun 6.
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Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.对 CCR5 抑制剂 5P12-RANTES 的耐药性需要 CCR5 向 CXCR4 辅助受体的艰难进化。
PLoS One. 2011;6(7):e22020. doi: 10.1371/journal.pone.0022020. Epub 2011 Jul 8.
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Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists.计算分析小分子拮抗剂抑制趋化因子受体 CXCR4 的结构机制。
Exp Biol Med (Maywood). 2011 Jul;236(7):844-50. doi: 10.1258/ebm.2011.010345. Epub 2011 Jun 22.
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Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.设计新型 CXCR4 拮抗剂，其为有效的 T 细胞嗜性（X4）HIV-1 复制抑制剂。
Bioorg Med Chem Lett. 2011 Mar 1;21(5):1414-8. doi: 10.1016/j.bmcl.2011.01.021. Epub 2011 Jan 11.
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Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.新型 CXCR4 拮抗剂的合成及构效关系研究，该拮抗剂对 T 嗜性（X4）HIV-1 复制具有强效抑制作用。
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Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20565-70. doi: 10.1073/pnas.1012865107. Epub 2010 Nov 8.
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