胎盘中二苯并[def,p] Chrysene（DBC）的致癌作用：母体暴露的时间决定了后代中靶组织的反应。
Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.
机构信息
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
出版信息
Cancer Lett. 2012 Apr 1;317(1):49-55. doi: 10.1016/j.canlet.2011.11.010. Epub 2011 Nov 13.
Abstract
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [(14)C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [(14)C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.
摘要
二苯并[def,p]苝（DBC）是一种在小鼠中具有胎盘转移致癌性的物质（15mg/kg；妊娠第 17 天）。为了模拟整个怀孕期间的残留暴露，母鼠在妊娠第 5、9、13 和 17 天接受了四次较小剂量的 DBC（3.75mg/kg）。该方案减轻了先前在胸腺、肺和肝脏中建立的致癌反应。然而，卵巢肿瘤（雌性）和增生睾丸（雄性）明显增加。在妊娠第 17 天给予 [(14)C]-DBC 后，与配对的母体组织相比，胎儿组织中的胎盘转移分布浓度低 10 倍，且 3 周后仍有 [(14)C]残留。这项研究强调了发育阶段对环境致癌物质易感性的重要性。
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