Komen Marion M C, Smorenburg Carolien H, van den Hurk Corina J G, Nortier J W R Hans
Medisch Centrum Alkmaar, afd. Oncologie, Alkmaar, the Netherlands.
Ned Tijdschr Geneeskd. 2011;155(45):A3768.
Alopecia is a very common side effect of cytostatic therapy and is considered one of the most emotionally distressing effects. To prevent alopecia scalp cooling is currently used in some indications in medical oncology in 59 hospitals in the Netherlands. The success of scalp cooling depends on various factors such as type of chemotherapy, dose, infusion time, number of treatment cycles and combinations of drugs. In general, scalp cooling is well tolerated. The reported side-effects are headache, coldness, dizziness and sometimes claustrophobia. An increase in the risk of scalp metastases has not been demonstrated. Proceeding from the South Netherlands Comprehensive Cancer Centre a national working group is put together in order to draw up a national guideline for chemotherapy-induced alopecia.
脱发是细胞毒性疗法非常常见的副作用，被认为是最令人情绪痛苦的影响之一。为预防脱发，荷兰59家医院的医学肿瘤学在某些适应症中目前采用头皮冷却法。头皮冷却的成功取决于多种因素，如化疗类型、剂量、输注时间、治疗周期数和药物组合。一般来说，头皮冷却耐受性良好。报告的副作用有头痛、寒冷、头晕，有时还有幽闭恐惧症。尚未证实头皮转移风险增加。以南荷兰综合癌症中心为起点，组建了一个全国性工作组，以制定化疗所致脱发的全国性指南。
