Eindhoven Cancer Registry/Comprehensive Cancer Centre South, Research Department, Eindhoven, The Netherlands.
Acta Oncol. 2012 Apr;51(4):497-504. doi: 10.3109/0284186X.2012.658966. Epub 2012 Feb 6.
Chemotherapy-induced alopecia is a frequently occurring side effect of cancer treatment with a high psychological impact which can be prevented by scalp cooling. With this multi-centre patient series we estimated the results of scalp cooling for currently used chemotherapies to provide patient information and we identified characteristics associated with the results.
The Dutch Scalp Cooling Registry collected data on scalp-cooled patients in 28 Dutch hospitals. Nurses and patients completed questionnaires on patients, chemotherapy and scalp cooling characteristics. Logistic regression analysis was used to examine associated characteristics of the scalp cooling result.
Overall, 50% of the 1411 scalp-cooled patients did not wear a head cover during their last chemotherapy session. Patients were satisfied with the results in 8% of cases after TAC chemotherapy and up to 95% after paclitaxel treatment. Besides type of chemotherapy, higher dose and shorter infusion time, older age, female gender and non-West-European type of hair significantly increased the proportion head cover use. Hair length, quantity, chemical manipulation (dyeing, waving, colouring), wetting hair before scalp cooling, and treatment with chemotherapy ever before did not influence the degree of head covering among patients.
Scalp cooling results as recorded in this open patient registry were positive for most regimens, justifying it's use by all eligible patients, except for those needing TAC. Lengthening infusion time may improve the results.
化疗引起的脱发是癌症治疗中一种常见的副作用，对患者心理影响较大，头皮冷却可预防脱发。本多中心患者系列研究旨在评估头皮冷却对目前常用化疗药物的效果，为患者提供信息，并确定与结果相关的特征。
荷兰头皮冷却登记处收集了 28 家荷兰医院接受头皮冷却治疗的患者数据。护士和患者完成了有关患者、化疗和头皮冷却特征的问卷。采用逻辑回归分析来研究与头皮冷却效果相关的特征。
在 1411 例接受头皮冷却的患者中，总体有 50%的患者在最后一次化疗时未戴头套。在接受 TAC 化疗的患者中，8%的患者对结果满意，而接受紫杉醇治疗的患者中高达 95%的患者满意。除化疗类型外，较高的剂量和较短的输注时间、年龄较大、女性和非西欧型发质显著增加了头套使用率。头发长度、数量、化学处理（染发、烫发、染色）、在头皮冷却前润湿头发以及之前是否接受过化疗治疗均不影响患者对头套的使用程度。
根据本开放患者登记处的记录，头皮冷却的结果对大多数方案都是积极的，除了需要 TAC 方案的患者外，应推荐所有符合条件的患者使用。延长输注时间可能会改善效果。
