Mars W M, Saunders G F
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston.
Cancer Metastasis Rev. 1990 Jul;9(1):35-43. doi: 10.1007/BF00047587.
This review emphasizes cytogenetic changes and DNA analyses by Southern blot in primary breast tumors, rather than metastases, established cell lines, and pleural effusions. The data suggests that the most frequently altered chromosomes and chromosome regions are 1p, 1q, 2q, 3p, 5, 6q, 8p, 8q, 11p, 11q, 12, 13q, 14q, 16, 17p, and 17q. Changes on 8q, 11p, 11q, 13q, and 17q appear to be associated with either progression of the disease or poor prognosis. Alterations on 1p and 3p may represent early events in the development of breast cancer.
本综述重点关注原发性乳腺肿瘤而非转移瘤、已建立的细胞系及胸腔积液中的细胞遗传学变化和Southern印迹法DNA分析。数据表明，最常发生改变的染色体及染色体区域为1p、1q、2q、3p、5、6q、8p、8q、11p、11q、12、13q、14q、16、17p和17q。8q、11p、11q、13q和17q上的变化似乎与疾病进展或预后不良相关。1p和3p上的改变可能代表乳腺癌发生过程中的早期事件。
