Larsson M, Edqvist L E, Ekman L, Persson S
Acta Vet Scand. 1979;20(1):16-24. doi: 10.1186/BF03546625.
Peripheral blood plasma Cortisol concentration and its diurnal variation was measured in 4 horses. Mean concentration of Cortisol during 24 hrs. was 42 ng/ml (s ± 20 ng/ml). Peak values occurred at 6 a.m. and the lowest values were observed at about 6 p.m. (mean 65 ng/ml and 20 ng/ml, respectively). Long-acting ACTH at a dose of 150 i.u. was given by intramuscular injection to the 4 horses. Peak Cortisol concentrations markedly exceeding the prestimulation level were obtained between 2 and 4 hrs. after injection. During the immediate 24 hrs. after these peaks, the mean Cortisol level was markedly lower and the cyclic variation out of phase with the basal diurnal pattern. After a gradual adjustment during the second postinjection day, no differences could be seen between the 2 patterns on day 3 after injection.
对4匹马的外周血浆皮质醇浓度及其昼夜变化进行了测量。24小时内皮质醇的平均浓度为42纳克/毫升（标准差±20纳克/毫升）。峰值出现在上午6点，最低值出现在下午6点左右（分别平均为65纳克/毫升和20纳克/毫升）。给这4匹马肌肉注射150国际单位的长效促肾上腺皮质激素。注射后2至4小时获得明显超过刺激前水平的皮质醇峰值浓度。在这些峰值出现后的紧接着24小时内，平均皮质醇水平明显较低，且周期性变化与基础昼夜模式不同步。在注射后的第二天逐渐调整后，注射后第三天这两种模式之间没有差异。
