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风险因素的协同效应。

Synergistic effects of risk factors.

作者信息

Wilhelmsen L

机构信息

Department of Medicine, Gothenburg University, Ostra Hospital, Sweden.

出版信息

Clin Exp Hypertens A. 1990;12(5):845-63. doi: 10.3109/10641969009073504.

DOI:10.3109/10641969009073504
PMID:2208755
Abstract

Risk factors for coronary heart disease (CHD), stroke, congestive heart failure and total mortality were analysed in two random population samples of men in Gothenburg, Sweden, aged 50 and 47-55 years, respectively, at entry. A series of potential risk factors for the above mentioned end-points have been analysed in univariate and multivariate logistic analyses. Population attributable risks were also calculated. Significant risk factors in multivariate analyses are summarized. For CHD they were: family history of CHD, hypercholesterolemia, hypertension, tobacco smoking, psychologic stress, low social class and diabetes mellitus. In hypertensives, proteinuria was measured and found to be significant also. Stroke risk factors were: family history of stroke, blood pressure, smoking, high waist/hip ratio, high plasma fibrinogen, psychologic stress, proteinuria, atria fibrillation and transitory ischemic attacks. Hypertension, smoking, high waist/hip ratio and psychologic stress were risk factors for congestive heart failure.

摘要

对瑞典哥德堡两个男性随机人群样本的冠心病(CHD)、中风、充血性心力衰竭和全因死亡率的危险因素进行了分析,入组时年龄分别为50岁以及47 - 55岁。对上述终点的一系列潜在危险因素进行了单变量和多变量逻辑分析。还计算了人群归因风险。总结了多变量分析中的显著危险因素。对于冠心病,它们是:冠心病家族史、高胆固醇血症、高血压、吸烟、心理压力、低社会阶层和糖尿病。在高血压患者中,测量了蛋白尿,发现其也具有显著性。中风的危险因素是:中风家族史、血压、吸烟、高腰臀比、高血浆纤维蛋白原、心理压力、蛋白尿、心房颤动和短暂性脑缺血发作。高血压、吸烟、高腰臀比和心理压力是充血性心力衰竭的危险因素。

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Bull World Health Organ. 1997;75(2):99-108.
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Effects of isradipine sustained release on platelet function and fibrinolysis in essential hypertensives with or without other risk factors.
Cardiovasc Drugs Ther. 1996 May;10(2):119-23. doi: 10.1007/BF00823589.
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BMJ. 1994 Jul 2;309(6946):11-5. doi: 10.1136/bmj.309.6946.11.
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Multiple cardiovascular disease risk factors in Canadian adults. Canadian Heart Health Surveys Research Group.加拿大成年人的多种心血管疾病风险因素。加拿大心脏健康调查研究小组。
CMAJ. 1992 Jun 1;146(11):2021-9.