Mahida Y R, Gallagher A, Kurlak L, Hawkey C J
Department of Therapeutics, University Hospital, Queen's Medical Centre, Nottingham, England, UK.
Clin Exp Immunol. 1990 Oct;82(1):75-80. doi: 10.1111/j.1365-2249.1990.tb05406.x.
Plasma and tissue interleukin-2 receptor (IL-2R) levels were determined in patients with active ulcerative colitis and Crohn's disease. Compared with healthy controls (median 440 U/ml; range 240-900), significantly higher levels of plasma IL-2R were present in patients with active ulcerative colitis (median 1180 U/ml; range 580-7150; P less than 0.002) and Crohn's disease (median 1340 U/ml; range 480-9000; P less than 0.002). Compared with other laboratory parameters, plasma IL-2R levels were related most closely to clinical score of disease activity in Crohn's disease. Plasma IL-2R levels also reflected the clinical course and may provide a more accurate assessment of disease activity in Crohn's disease. In plasma of patients undergoing intestinal resection of active inflammatory bowel disease, raised levels of IL-2R were present in samples from mesenteric vein (draining inflamed intestine) compared with those from peripheral vein. In tissue homogenates of colonic biopsies, significantly higher levels of IL-2R were present in specimens from colons with active ulcerative colitis compared with healthy controls (median 230.2, range 20.7-581.5 versus 77.9, range 34.2-291.3; P less than 0.02).
测定了活动性溃疡性结肠炎和克罗恩病患者血浆和组织白细胞介素 - 2受体（IL - 2R）水平。与健康对照者（中位数440 U/ml；范围240 - 900）相比，活动性溃疡性结肠炎患者（中位数1180 U/ml；范围580 - 7150；P < 0.002）和克罗恩病患者（中位数1340 U/ml；范围480 - 9000；P < 0.002）的血浆IL - 2R水平显著更高。与其他实验室参数相比，血浆IL - 2R水平与克罗恩病疾病活动临床评分的相关性最为密切。血浆IL - 2R水平也反映了临床病程，并且可能为克罗恩病的疾病活动提供更准确的评估。在接受活动性炎症性肠病肠切除术患者的血浆中，与外周静脉血样相比，肠系膜静脉（引流发炎肠道）血样中的IL - 2R水平升高。在结肠活检组织匀浆中，与健康对照者相比，活动性溃疡性结肠炎结肠标本中的IL - 2R水平显著更高（中位数230.2，范围20.7 - 581.5对77.9，范围34.2 - 291.3；P < 0.02）。
