登革热感染的血清流行率：坦桑尼亚大陆和桑给巴尔奔巴岛的横断面调查。
Seroprevalence of dengue infection: a cross-sectional survey in mainland Tanzania and on Pemba Island, Zanzibar.
机构信息
National Institute for Infectious Diseases, "L. Spallanzani", Rome, Italy.
出版信息
Int J Infect Dis. 2012 Jan;16(1):e44-6. doi: 10.1016/j.ijid.2011.09.018. Epub 2011 Nov 15.
OBJECTIVE
Evidence available to date indicates that dengue viruses 1, 2, and 3 could be among the causes of acute fever in eastern Africa. Recently, four reports on dengue infection in travelers and residents have raised concerns over the occurrence of dengue fever in mainland Tanzania and in Zanzibar. The objective of this study was to provide seroprevalence data on dengue infection in Tanzania.
METHODS
This study was conducted in 2007 at two peripheral hospitals, one on Pemba Island, Zanzibar and one in Tosamaganga, Iringa Region, mainland Tanzania. Two hundred and two consecutive febrile outpatients were studied for antibodies and viral RNA to assess the circulation of dengue virus in Tanzania.
RESULTS
A seroprevalence of 7.7% was found on Pemba Island and of 1.8% was found in Tosamaganga. No acute cases and no previous infections among patients under 11 years of age were detected.
CONCLUSION
These findings provide the first baseline data on dengue seroprevalence in the country. No recent dengue virus circulation in Tanzania and in the Zanzibar archipelago up until the early 1990s is reported.
目的
现有证据表明，登革热病毒 1、2 和 3 可能是引起东非急性发热的原因之一。最近，有 4 份关于旅行者和居民中登革热感染的报告引起了人们对坦桑尼亚大陆和桑给巴尔岛登革热发生的关注。本研究的目的是提供坦桑尼亚登革热感染的血清流行率数据。
方法
本研究于 2007 年在两个外围医院进行，一个在桑给巴尔的奔巴岛，一个在坦桑尼亚伊林加地区的托萨马甘加。对 202 例连续发热的门诊患者进行了抗体和病毒 RNA 检测，以评估坦桑尼亚登革热病毒的流行情况。
结果
奔巴岛上的血清阳性率为 7.7%，托萨马甘加的血清阳性率为 1.8%。未发现急性病例，也未发现 11 岁以下患者的既往感染。
结论
这些发现提供了该国登革热血清流行率的首个基线数据。报告称，直到 20 世纪 90 年代初，坦桑尼亚和桑给巴尔群岛都没有最近的登革热病毒传播。
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