Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA.
J Clin Neurosci. 2012 Jan;19(1):163-6. doi: 10.1016/j.jocn.2011.07.016. Epub 2011 Nov 15.
Central neurocytomas (CN) are benign central nervous system (CNS) tumors of neuroglial origin that represent 0.25 to 0.5% of all intracranial tumors in adults and an even smaller proportion of pediatric CNS tumors. These tumors characteristically occur in the subependymal layer of the lateral ventricle near the foramen of Monro and appear as sharply demarcated, solitary lesions. Surgical resection is considered curative, as the reported recurrence rate is less than 5% for patients with localized disease. In this report, we describe the case of a three-year-old boy with a diffuse CN with craniospinal dissemination identified at the time of diagnosis. Given the extensive nature of the disease, surgical resection was not indicated and he underwent a chemotherapeutic regimen of vincristine and carboplatin. At 18 months followup, the patient has completed 6 of 8 total cycles of vincristine and carboplatin and serial imaging shows stable disease within the craniospinal axis.
中枢神经细胞瘤（CN）是一种起源于神经胶质的良性中枢神经系统（CNS）肿瘤，占成人颅内肿瘤的 0.25%至 0.5%，在儿童 CNS 肿瘤中所占比例更小。这些肿瘤通常发生在侧脑室的室管膜下层，靠近孟氏孔，表现为界限清楚的单发病变。手术切除被认为是治愈性的，因为对于局限性疾病患者，报告的复发率低于 5%。在本报告中，我们描述了一名三岁男孩的病例，该男孩在诊断时即存在弥漫性 CN 伴颅脊髓播散。鉴于疾病的广泛性，手术切除不适用，他接受了长春新碱和卡铂的化疗方案。在 18 个月的随访中，患者已完成 8 个周期长春新碱和卡铂的 6 个周期，连续影像学检查显示颅脊髓轴内疾病稳定。
