School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, NSW, Australia.
Mucosal Immunol. 2012 Jan;5(1):7-18. doi: 10.1038/mi.2011.55. Epub 2011 Nov 16.
Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.
慢性阻塞性肺疾病（COPD）和炎症性肠病（IBD）分别是影响呼吸道和胃肠道的两种慢性黏膜组织炎症性疾病。它们在流行病学和临床特征方面以及在炎症病理方面有许多相似之处。重要的是，这两种疾病都伴有全身性合并症，但在基础和临床研究中都在很大程度上被忽视了。因此，考虑这些并发症可能会使预防和治疗方法的效果最大化。在这里，我们研究了 COPD 的肠道受累和 IBD 的肺部表现。我们还回顾了可能驱动这些关联的炎症器官交叉对话的证据，并讨论了这些问题的当前研究前沿。
