Clerget Emeline, Badets Arnaud, Duqué Julie, Olivier Etienne
Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.
Neuroreport. 2011 Dec 21;22(18):965-9. doi: 10.1097/WNR.0b013e32834d87cd.
Besides language, the contribution of Broca's area to motor cognition is now widely accepted. In this study, we investigated the role of its posterior part (left Brodmann area 44) in learning of a motor sequence by altering its functioning with a continuous theta-burst transcranial magnetic stimulation (cTBS) in 12 healthy participants before they learned the sequence by observation. Twelve control individuals underwent the same experiment with cTBS applied over the vertex. Although cTBS over Brodmann area 44 did not impair sequence learning, it significantly increased the response latency as measured during the retention test, performed 24 h later. This finding suggests that Broca's area might be critically involved in organizing, and/or storing, the individual components of a motor sequence before its execution.
除了语言功能外，布罗卡区对运动认知的贡献现在已被广泛认可。在本研究中，我们通过在12名健康参与者观察学习运动序列之前，使用连续theta爆发式经颅磁刺激（cTBS）改变其左脑44区（布罗德曼区）后部的功能，来研究该区域在运动序列学习中的作用。12名对照个体在头顶进行相同的cTBS实验。尽管对44区进行cTBS并没有损害序列学习，但在24小时后进行的保持测试中，显著增加了反应潜伏期。这一发现表明，布罗卡区可能在运动序列执行前对其各个组成部分的组织和/或存储起着关键作用。
