Corcho-Berdugo Alexander, Muñoz-Hernández Bertha, Palma-Cortés Gabriel, Ramírez-Hernández Amado, Martínez-Rivera María, Frías-de León María, Reyes-Montes María, Martínez-Valadez Eduarda, Manjarrez-Zavala María, Alfaro-Ramos Leticia, Higuera-Iglesias Anjarath Lorena
Departamento de Investigación en Epidemiología Clínica, Instituto Nacional de Enfermedades Respiratorias, México.
Gac Med Mex. 2011 Sep-Oct;147(5):377-84.
The aim of this study was to establish whether there was a histoplasmosis outbreak among a group of residents of Naucalpan (State of Mexico, a non-endemic area for histoplasmosis) and to ascertain the source through which they were infected.
Anyone associated with the Index Case in the same period with a flu-like infection was considered as a suspected case. Diagnosis was confirmed by clinical examination positive, cultures and positive immunological tests. Date and form of potential exposure were obtained through interviews. Material potentially contaminated with bird or bat droppings was sought and analyzed by PCR.
The outbreak was associated with a trip to El Tamarindo (Veracruz, near the Gulf of Mexico). Patients got sick after digging a hole in the floor inside a house where a treasure had been supposedly buried by a death relative. The pathogen was detected in soil samples at 10 cm below the surface.
The study showed that patients contracted histoplasmosis in El Tamarindo, a community where there had been no prior cases of this disease.
本研究旨在确定墨西哥州瑙卡尔潘（组织胞浆菌病非流行地区）的一组居民中是否存在组织胞浆菌病暴发，并查明他们的感染源。
将同期与索引病例有流感样感染关联的任何人视为疑似病例。通过临床检查阳性、培养和免疫检测阳性来确诊。通过访谈获取潜在暴露的日期和形式。寻找可能被鸟类或蝙蝠粪便污染的材料，并通过聚合酶链反应（PCR）进行分析。
此次暴发与前往埃尔塔马林多（韦拉克鲁斯州，靠近墨西哥湾）的旅行有关。患者在一所房子里挖一个据说被已故亲属埋藏宝藏的地板洞后生病。在地表以下10厘米处的土壤样本中检测到病原体。
该研究表明，患者在埃尔塔马林多感染了组织胞浆菌病，该社区此前没有这种疾病的病例。
