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DABCO 催化的β,γ-不饱和α-酮膦酸酯或β,γ-不饱和α-酮酸酯与烯丙基酯的区域选择性环化反应。

DABCO-catalyzed regioselective cyclization reactions of β,γ-unsaturated α-ketophosphonates or β,γ-unsaturated α-ketoesters with allenic esters.

机构信息

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.

出版信息

Org Biomol Chem. 2012 Jan 7;10(1):171-80. doi: 10.1039/c1ob06507f. Epub 2011 Nov 17.

DOI:10.1039/c1ob06507f
PMID:22089699
Abstract

Highly efficient DABCO-catalyzed [4 + 2] cycloaddition of β,γ-unsaturated α-ketophosphonates or β,γ-unsaturated α-ketoesters with allenic esters gives the corresponding highly functionalized tetrahydropyran and dihydropyran derivatives in good to excellent yields and moderate to good regioselectivities under mild conditions.

摘要

高催化效率的 DABCO 催化β,γ-不饱和α-酮膦酸酯或β,γ-不饱和α-酮酸酯与烯丙基酯的[4+2]环加成反应，在温和条件下以良好至优秀的收率和中等至良好的区域选择性得到相应的高官能化四氢吡喃和二氢吡喃衍生物。

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