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从不对称的 [4 + 2] 环加成β,γ-不饱和α-酮酯与烯丙酯合成光学活性二氢吡喃。

Synthesis of optically active dihydropyrans from asymmetric [4 + 2] cycloaddition of β,γ-unsaturated α-ketoesters with allenic esters.

机构信息

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.

出版信息

Org Biomol Chem. 2012 Jun 14;10(22):4355-61. doi: 10.1039/c2ob25475a. Epub 2012 May 3.

DOI:10.1039/c2ob25475a
PMID:22555871
Abstract

β-Isocupreidine (β-ICD) catalyzed asymmetric [4 + 2] cycloaddition of β,γ-unsaturated α-ketoesters with allenic esters afforded ester-substituted functionalized dihydropyran derivatives in high yields along with high enantioselectivities under mild conditions.

摘要

β-异芦竹碱（β-ICD）催化β,γ-不饱和α-酮酸酯与烯丙基酯的不对称[4+2]环加成反应，在温和条件下以高产率和高对映选择性得到酯取代的官能化二氢吡喃衍生物。

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