Paul-Ehrlich-Institut, Langen, Germany.
J Virol. 2012 Feb;86(3):1893-6. doi: 10.1128/JVI.05198-11. Epub 2011 Nov 16.
Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.
干扰素刺激基因发挥先天抗病毒效应功能。其中， tetherin（THN）可阻止多种包膜病毒从感染细胞中释放。痘苗病毒（VACV）编码的免疫调节剂可干扰抗病毒宿主反应。因此，研究 VACV-THN 相互作用具有很大吸引力。值得注意的是，THN 表达并不抑制 VACV 的释放和复制。VACV 感染不会降低 THN 表面水平或损害其在逆转录病毒释放中的功能。这表明 THN 不能限制 VACV 的复制。
