Department of Psychiatry, Tokyo Jikei University School of Medicine, Tokyo, Japan.
Neuropsychiatr Dis Treat. 2011;7:655-62. doi: 10.2147/NDT.S25504. Epub 2011 Nov 1.
Polycystic ovary syndrome (PCOS) is a common lifestyle-related endocrinopathy in women of reproductive age and is associated with several mental health problems. We examined the genotypic distributions of IRS-1 Gly972Arg and CYP11B2 -344T/C, which were previously described as influencing PCOS, and assayed the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in a set of female patients with borderline personality disorder (BPD) with comorbid major depressive disorder (MDD) (n = 50) and age-matched control subjects (n = 100), to investigate the predisposition for BPD with MDD. The results showed that the patients were more frequently IRS-1 972Arg variant allele carriers (P = 0.013; OR 6.68; 95% CI = 1.30-34.43) and homozygous for the CYP11B2 -344C variant allele (P = 0.022; OR = 3.32; 95% CI = 1.18-9.35) than the control subjects. The IL-6 level was significantly higher in the patients than in the controls (P < 0.0001). There was no significant difference in the serum TNF-α level between patients with BPD with MDD and the healthy comparison group (P = 0.5273). In conclusion, the predisposition for BPD with MDD is associated with that for PCOS, in the female Japanese population. An elevated serum IL-6 level is considered to be a possible biomarker of BPD with MDD.
多囊卵巢综合征（PCOS）是一种常见的与生活方式相关的育龄期女性内分泌疾病，与多种心理健康问题有关。我们研究了 IRS-1 Gly972Arg 和 CYP11B2-344T/C 的基因型分布，先前的研究表明这两种基因与 PCOS 有关，同时检测了一组伴发重度抑郁症的边缘型人格障碍女性患者（n=50）和年龄匹配的对照组（n=100）的血清白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平，以探讨伴发重度抑郁症的边缘型人格障碍的易感性。结果表明，患者 IRS-1 972Arg 变异等位基因携带者的频率更高（P=0.013；OR 6.68；95%CI=1.30-34.43），并且 CYP11B2-344C 变异等位基因纯合子的频率也更高（P=0.022；OR=3.32；95%CI=1.18-9.35）。患者的血清 IL-6 水平明显高于对照组（P<0.0001）。伴发重度抑郁症的边缘型人格障碍患者与健康对照组之间的血清 TNF-α水平无显著差异（P=0.5273）。总之，在日本女性人群中，伴发重度抑郁症的边缘型人格障碍的易感性与 PCOS 相关。血清 IL-6 水平升高被认为是伴发重度抑郁症的边缘型人格障碍的一个可能的生物标志物。
