Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77, Stockholm, Sweden.
Psychoneuroendocrinology. 2017 Nov;85:63-68. doi: 10.1016/j.psyneuen.2017.08.007. Epub 2017 Aug 10.
Women with polycystic ovary syndrome (PCOS) are at elevated risk for suffering from depression. Neuroticism is a personality trait that has been associated with an increased risk for developing major depressive disorder (MDD). The aim of the present study was to quantify and decompose the correlation between neuroticism, PCOS, and MDD into shared and unique genetic and environmental etiologies, by using quantitative genetic methods.
In a cohort of 12,628 Swedish female twins born from 1959 to 1985, neuroticism, PCOS identified by symptoms of hyperandrogenemia (i.e., hirsutism) and oligo- and/or anovulation, and lifetime MDD status were determined through questionnaire responses. Structural equation modeling was used to study the genetic and environmental sources of the variation within, and covariation between neuroticism, PCOS, and MDD.
Female twins with PCOS (n=752) had significantly higher levels of neuroticism than women without PCOS, and a 2-fold increase in odds for a lifetime prevalence of MDD. The phenotypic correlation between PCOS and MDD was 0.19, with 63% of the correlation attributable to common genetic factors between the two traits. When taking into account neuroticism, 41% was attributable to common genetic factors and 9% attributable to common environmental factors shared between all three traits, with the remainder attributable to components unique to PCOS and MDD.
There are common genetic factors between neuroticism, PCOS, and MDD; however, neuroticism shares approximately half of the genetic and environmental components behind the phenotypic correlation between PCOS and MDD, providing some etiological evidence behind the comorbidity between PCOS and depression.
多囊卵巢综合征（PCOS）女性患抑郁症的风险增加。神经质是一种人格特质，与发生重度抑郁症（MDD）的风险增加有关。本研究的目的是通过定量遗传方法，量化和分解神经质、PCOS 和 MDD 之间的相关性为共享和独特的遗传和环境病因。
在 1959 年至 1985 年出生的 12628 名瑞典女性双胞胎队列中，通过问卷调查确定神经质、PCOS（通过高雄激素血症（即多毛症）和寡排卵和/或无排卵的症状来识别）和终生 MDD 状态。使用结构方程模型研究神经质、PCOS 和 MDD 内部和之间变异的遗传和环境来源。
患有 PCOS 的女性双胞胎（n=752）的神经质水平明显高于没有 PCOS 的女性，并且终生 MDD 患病率的几率增加了两倍。PCOS 和 MDD 之间的表型相关性为 0.19，其中两个特征之间的相关性有 63%归因于共同的遗传因素。当考虑神经质时，41%归因于共同的遗传因素，9%归因于所有三个特征之间共同的环境因素，其余归因于 PCOS 和 MDD 特有的成分。
神经质、PCOS 和 MDD 之间存在共同的遗传因素；然而，神经质共享 PCOS 和 MDD 之间表型相关性背后的遗传和环境成分的大约一半，为 PCOS 和抑郁共病提供了一些病因学证据。
