Ye C Y, He X H, Chen J S
County Hospital of Hui-an, Fujian.
Zhonghua Nei Ke Za Zhi. 1990 Feb;29(2):76-8, 125.
The results of atropine treatment in 506 cases of severe organic phosphorus pesticide intoxication are reported. Among the variables which might effect the results of treatment, the average dosage of atropine was related intimately to the prognosis (standard coefficient of regression bi = 0.4702, P less than 0.01). When the average drug dosage was 40-80 ng/h, the mortality was 26.6% and much lower than other groups (P less than 0.01). Intravenous administration given at regular intervals was better than continuous drip; the mortality dropped to 61.2% from 90.9% (P less than 0.01). Both inadequate atropinization and atropine intoxication were less frequently seen during intermitten injection (P less than 0.01).
报告了506例重度有机磷农药中毒患者的阿托品治疗结果。在可能影响治疗结果的变量中，阿托品的平均剂量与预后密切相关（回归标准系数bi = 0.4702，P < 0.01）。当平均药物剂量为40 - 80 ng/h时，死亡率为26.6%，远低于其他组（P < 0.01）。定期静脉给药优于持续滴注；死亡率从90.9%降至61.2%（P < 0.01）。在间歇注射期间，阿托品化不足和阿托品中毒的情况都较少见（P < 0.01）。
