Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.
Dermatol Surg. 2011 Dec;37(12):1770-5. doi: 10.1111/j.1524-4725.2011.02164.x. Epub 2011 Oct 20.
Although hyaluronic acid (HA) fillers are extensively used for the correction of facial wrinkles and folds, there is a limit to patient satisfaction, especially in patients with severe wrinkles.
To evaluate the potential for synergistic effects with combined treatment using a nonablative infrared (IR) device and HA filler in the treatment of nasolabial fold (NLF) wrinkles.
This was a split-face randomized study in which 12 Korean patients were treated with HA filler on both NLFs and with a nonablative IR device on the experimental side of the face. Clinical evaluations from subjects and investigators and photographs were obtained at baseline, just before and after the procedures, and 1 and 2 months after completion of the procedures.
There were no significant differences between wrinkle severity and global aesthetic scores for HA gel implantation alone and HA gel with nonablative IR device treatment at any point.
Combining the use of a nonablative IR device with HA filler does not appear to be superior to HA filler alone in the treatment of moderate to severe NLF wrinkles.
尽管透明质酸（HA）填充剂被广泛用于纠正面部皱纹和褶皱，但患者的满意度仍存在一定限制，尤其是对于重度皱纹患者。
评估联合使用非剥脱性近红外（IR）设备和 HA 填充剂治疗鼻唇沟（NLF）皱纹的协同作用潜力。
这是一项半脸随机研究，其中 12 名韩国患者在 NLF 两侧接受 HA 填充剂治疗，并在面部的实验侧接受非剥脱性 IR 设备治疗。在基线、治疗前后即刻以及治疗完成后 1 个月和 2 个月，由受试者和研究者进行临床评估并拍摄照片。
在任何时间点，单独使用 HA 凝胶植入和 HA 凝胶联合非剥脱性 IR 设备治疗的皱纹严重程度和整体美学评分均无显著差异。
在治疗中重度 NLF 皱纹方面，联合使用非剥脱性 IR 设备和 HA 填充剂似乎并不优于单独使用 HA 填充剂。
