Kobayashi D, Kogawa K, Imai K, Tanaka T, Hiroi S, Satoh H, Tanaka-Taya K, Nonoyama S
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201-2119, USA.
Transpl Infect Dis. 2011 Dec;13(6):650-3. doi: 10.1111/j.1399-3062.2011.00693.x. Epub 2011 Nov 17.
Chromosomal integration of the human herpesvirus-6 (HHV-6) genome (CIHHV-6) is an important consideration if HHV-6 DNA is detected during the course of transplantation. A 4-year-old girl with refractory anemia with excess blasts type-2 was diagnosed with CIHHV-6 before a cord blood transplantation. HHV-6 DNA was serially quantitated by polymerase chain reaction assay in the transplant period. The possibility of HHV-6 reactivation in a transplant recipient with CIHHV-6 was suspected in our case.
如果在移植过程中检测到人类疱疹病毒6型（HHV-6）DNA，那么人类疱疹病毒6型基因组的染色体整合（CIHHV-6）就是一个重要的考量因素。一名患有2型原始细胞增多的难治性贫血的4岁女孩在进行脐血移植前被诊断为CIHHV-6。在移植期间通过聚合酶链反应分析对HHV-6 DNA进行了连续定量。在我们的病例中，怀疑CIHHV-6移植受者中存在HHV-6再激活的可能性。
