治愈所有急性早幼粒细胞白血病患者：我们做到了吗？
Curing all patients with acute promyelocytic leukemia: are we there yet?
机构信息
Department of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, 525 East 68th Street, Box 130, New York, NY 10065, USA.
出版信息
Hematol Oncol Clin North Am. 2011 Dec;25(6):1215-33, viii. doi: 10.1016/j.hoc.2011.10.002.
Abstract
The introduction of all-trans retinoic acid to anthracycline-based chemotherapy has revolutionized the prognosis of patients with acute promyelocytic leukemia (APL). The introduction of arsenic trioxide enabled the therapeutic approach of rationally targeted frontline protocols with minimal or no traditional cytotoxic chemotherapy and without compromise of previously established outstanding outcomes with anthracycline-based regimens. Although most of the current investigative efforts in APL are focused on developing potentially curative therapy without the exposure to toxicities and risks of DNA-disrupting agents, the cure rate can further be increased by implementing meticulous supportive care strategies that counter early coagulopathy-related deaths.
摘要
全反式维甲酸的引入彻底改变了急性早幼粒细胞白血病（APL）患者的预后。三氧化二砷的引入使我们能够采用合理靶向的一线方案进行治疗，而无需使用传统细胞毒化疗药物，且不影响基于蒽环类药物的方案所确立的卓越疗效。尽管目前 APL 的大部分研究工作都集中在开发潜在的治愈性疗法，以避免接触到具有细胞毒性和破坏 DNA 作用的药物，但通过实施细致的支持治疗策略来对抗早期与凝血功能障碍相关的死亡，可进一步提高治愈率。
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