Chen Mao-Gang, Zhu Wu-Sheng, Yin Qin, Wu Bo-Na, Wang Qi-Zhang, Ma Min-Min, Liu De-Zhi, Li Yong-Kun, Liu Chao-Lai, Huang Xian-Jun, Chen Zhao-Yao, Wang Wan-Xiang, Xu Ge-Lin, Liu Xin-Feng
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Zhonghua Yi Xue Za Zhi. 2011 Jul 5;91(25):1753-6.
To investigate the association of plasma homocysteine and OSA (obstructive sleep apnea) syndrome in ischemic stroke (IS).
A total of 92 male IS patients were classified by apnea hypopnea index (AHI) into 2 groups: non-OSA group (AHI < 5/h) and OSA group (AHI > or = 5). All patients were tested for plasma homocysteine when polysomnography was finished at (14 +/- 2) d after the onset of IS.
The mean level of homocysteine was significantly higher in the OSA group than that in the non-OSA group (17 +/- 5 vs 11 +/- 3 micromol/L, P < 0.01). Pearson correlation analysis revealed a positive correlation between the homocysteine level and the severity of AHI (r = 0.482, P < 0.01). Further multiple linear regression analysis showed that AHI and folate were independent predictors of homocysteine level (R2 = 0.553, P < 0.01, beta for AHI = 0.671, beta for folate = -0.256).
The severity of OSA is significantly associated with an elevated level of homocysteine in IS patients. And this association is independent of other causative factors of an elevated level of homocysteine.
探讨缺血性卒中（IS）患者血浆同型半胱氨酸与阻塞性睡眠呼吸暂停（OSA）综合征之间的关联。
将92例男性IS患者根据呼吸暂停低通气指数（AHI）分为两组：非OSA组（AHI<5次/小时）和OSA组（AHI≥5次/小时）。所有患者在IS发病后（14±2）天完成多导睡眠图检查时检测血浆同型半胱氨酸。
OSA组同型半胱氨酸平均水平显著高于非OSA组（17±5对11±3μmol/L，P<0.01）。Pearson相关分析显示同型半胱氨酸水平与AHI严重程度呈正相关（r=0.482，P<0.01）。进一步的多元线性回归分析表明，AHI和叶酸是同型半胱氨酸水平的独立预测因素（R2=0.553，P<0.01，AHI的β=0.671，叶酸的β=-0.256）。
OSA的严重程度与IS患者同型半胱氨酸水平升高显著相关。并且这种关联独立于同型半胱氨酸水平升高的其他致病因素。
