Jacobs S, George A, Papanicolaou G A, Lacouture M E, Tan B H, Jakubowski A A, Kaltsas A
Division of Infectious Diseases, New York Presbyterian Hospital - Weill Cornell, New York, New York, USA.
Transpl Infect Dis. 2012 Aug;14(4):410-4. doi: 10.1111/j.1399-3062.2011.00681.x. Epub 2011 Sep 8.
Mycobacterium marinum is a photochromogenic mycobacterium that is ubiquitous in the aquatic environment. In the general population, exposure to aquaria is the most common cause of M. marinum infection. Known as "swimmer's granuloma" or "fish tank granuloma," M. marinum is an occupational hazard for aquarium cleaners and fishermen. There are several reports in the literature of M. marinum infection in immunocompromised hosts, including those with solid organ transplants, but none in patients who have received stem cell transplants (SCTs). To our knowledge, this is a first report of disseminated M. marinum infection in an SCT recipient who continued to develop new skin lesions even after months of targeted therapy. The implications are that elderly patients who receive T-cell-depleted SCTs may be at prolonged risk for pathogens dependent on cellular immunity, and the presentation of illness with such pathogens may be more severe and widely disseminated than might otherwise be expected.
海分枝杆菌是一种光产色分枝杆菌，在水生环境中普遍存在。在普通人群中，接触水族箱是海分枝杆菌感染最常见的原因。海分枝杆菌被称为“游泳者肉芽肿”或“鱼缸肉芽肿”，是水族箱清洁人员和渔民的职业危害。文献中有几例免疫功能低下宿主感染海分枝杆菌的报道，包括实体器官移植者，但接受干细胞移植（SCT）的患者中尚无此类报道。据我们所知，这是首例关于SCT受者播散性海分枝杆菌感染的报道，该患者即使经过数月的靶向治疗仍不断出现新的皮肤病变。这意味着接受T细胞耗竭SCT的老年患者可能长期面临依赖细胞免疫的病原体感染风险，并且此类病原体所致疾病的表现可能比预期更为严重且播散范围更广。
