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[眼部的环磷酸鸟苷及其与外用胰岛素的相关性]

[Cyclic GMP in the eye and its correlation with externally administered insulin].

作者信息

Polychroniadis F, Livanou T, Tsimbidas P

出版信息

J Fr Ophtalmol. 1979 Feb;2(2):81-4.

PMID:220940
Abstract

Experiments carried on Albino rabbits for detecting cyclic GMP in the eye tissues and to observe whether cGMP is influenced through local administration of insulin to the eye, externally. Whereas, for instance, intraveinous administration of insulin does not influence, in any way, concentration of cGMP -- after 3' to 10' -- in the humour aqueous, the lens, the vitreous body and the blood serum, following administration of insulin by means of retrobulbar injection, for the same time and on the same tissues, the values of cGMP appear increased. On the other hand, results yielded by our experiments allow us to estimate that environment preparing cGMP in the eye is the retina and the choroid.

摘要

对白化兔进行实验,以检测眼组织中的环磷酸鸟苷(cGMP),并观察通过向眼局部外用胰岛素是否会影响cGMP。例如,静脉注射胰岛素在任何情况下都不会影响房水、晶状体、玻璃体和血清中cGMP的浓度(在注射后3至10分钟),而通过球后注射胰岛素,在相同时间对相同组织进行检测时,cGMP的值会升高。另一方面,我们的实验结果使我们估计,眼内产生cGMP的环境是视网膜和脉络膜。

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