Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland.
Eur Heart J Cardiovasc Imaging. 2012 Jan;13(1):51-60. doi: 10.1093/ejechocard/jer240. Epub 2011 Nov 17.
Cardiac hybrid imaging combines different imaging modalities in a way where both modalities equally contribute to image information. The most common and best-studied approach is to combine computed tomography coronary angiography (CTCA) and myocardial perfusion imaging either with single-photon emission computed tomography or with positron emission tomography (PET). This combination is a promising tool for evaluation of coronary artery disease since it allows visualization of coronary atherosclerotic lesions and their haemodynamic consequences in a single study and it appears to offer superior diagnostic accuracy when compared with stand-alone imaging. More recent applications are a combination of CTCA and cardiac magnetic resonance imaging by using software image fusion and utilization of commercially available hybrid PET/MRI scanners for cardiac applications. Currently, these methods have been reported only as case reports, but several potential applications also in cardiology can be anticipated. The development of new molecular imaging probes will also open completely new possibilities for guidance and monitoring of advanced therapies. This review will focus on the concepts and currently available clinical experiences from cardiac hybrid imaging as well as discuss the potential future applications.
心脏混合成像以一种两种模态对图像信息贡献相当的方式结合了不同的成像模态。最常见和研究最多的方法是将计算机断层冠状动脉造影（CTCA）和心肌灌注成像与单光子发射计算机断层扫描或正电子发射断层扫描（PET）相结合。这种组合是评估冠状动脉疾病的有前途的工具，因为它允许在单次研究中可视化冠状动脉粥样硬化病变及其血液动力学后果，并且与单独成像相比似乎具有更高的诊断准确性。最近的应用是通过使用软件图像融合将 CTCA 和心脏磁共振成像相结合，并利用市售的混合 PET/MRI 扫描仪进行心脏应用。目前，这些方法仅作为病例报告报道，但预计在心脏病学中也有一些潜在的应用。新的分子成像探针的开发也将为先进治疗的指导和监测开辟全新的可能性。本综述将重点介绍心脏混合成像的概念和目前可用的临床经验，并讨论潜在的未来应用。
