基于正电子发射断层扫描（PET）的缺血性心脏病成像
PET-Based Imaging of Ischemic Heart Disease.
作者信息
Chen Kevin, Miller Edward J, Sadeghi Mehran M
机构信息
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA.
出版信息
PET Clin. 2019 Apr;14(2):211-221. doi: 10.1016/j.cpet.2018.12.003. Epub 2019 Feb 1.
Abstract
PET-based cardiac nuclear imaging plays a large role in the management of ischemic heart disease. Compared with conventional single-photon emission CT myocardial perfusion imaging, PET provides superior accuracy in diagnosis of coronary artery disease and, with the incorporation of myocardial blood flow and coronary flow reserve, adds value in assessing prognosis for established coronary and microvascular disease. This review describes these and other uses of PET in ischemic heart disease, including assessing myocardial viability in ischemic cardiomyopathy. Developments in novel PET flow tracers and molecular imaging tools to assess atherosclerotic plaque vulnerability, vascular calcification, and vascular remodeling also are described.
摘要
基于正电子发射断层扫描（PET）的心脏核成像在缺血性心脏病的管理中发挥着重要作用。与传统的单光子发射计算机断层扫描心肌灌注成像相比，PET在冠状动脉疾病的诊断中具有更高的准确性，并且通过结合心肌血流和冠状动脉血流储备，在评估已确诊的冠状动脉和微血管疾病的预后方面具有附加价值。本综述描述了PET在缺血性心脏病中的这些及其他用途，包括评估缺血性心肌病中的心肌存活情况。还介绍了新型PET血流示踪剂以及用于评估动脉粥样硬化斑块易损性、血管钙化和血管重塑的分子成像工具的进展。
相似文献
1
PET-Based Imaging of Ischemic Heart Disease.基于正电子发射断层扫描（PET）的缺血性心脏病成像
PET Clin. 2019 Apr;14(2):211-221. doi: 10.1016/j.cpet.2018.12.003. Epub 2019 Feb 1.
2
Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.冠状动脉疾病的多中心多设备混合成像研究：缺血性心脏病检测与特征评估综合心脏成像（EVINCI）混合成像人群的研究结果
Eur Heart J Cardiovasc Imaging. 2016 Sep;17(9):951-60. doi: 10.1093/ehjci/jew038. Epub 2016 Mar 18.
3
Comparison of Coronary CT Angiography, SPECT, PET, and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve.冠状动脉 CT 血管造影、SPECT、PET 和混合成像在以血流储备分数确定的缺血性心脏病诊断中的比较。
JAMA Cardiol. 2017 Oct 1;2(10):1100-1107. doi: 10.1001/jamacardio.2017.2471.
4
Hybrid Imaging in Ischemic Heart Disease.缺血性心脏病中的混合成像
Rev Esp Cardiol (Engl Ed). 2018 May;71(5):382-390. doi: 10.1016/j.rec.2017.11.023. Epub 2018 Jan 10.
5
Update on myocardial blood flow quantification by positron emission tomography.正电子发射断层扫描心肌血流定量的更新。
Rev Port Cardiol (Engl Ed). 2020 Jan;39(1):37-46. doi: 10.1016/j.repc.2019.05.014. Epub 2020 Mar 4.
6
Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease-state-of-the-evidence and clinical recommendations.女性稳定型缺血性心脏病心肌灌注成像评估——证据现状与临床推荐。
J Nucl Cardiol. 2017 Aug;24(4):1402-1426. doi: 10.1007/s12350-017-0926-8. Epub 2017 Jun 5.
7
Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis.使用320排CT动态血管造影和运动相干图像处理技术对冠状动脉血流进行定量分析：检测中度冠状动脉狭窄的缺血情况。
Eur J Radiol. 2016 May;85(5):996-1003. doi: 10.1016/j.ejrad.2016.02.027. Epub 2016 Mar 2.
8
Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study.心脏N-13正电子发射断层扫描心肌血流储备分数用于缺血性冠状动脉疾病解剖与功能联合诊断的益处：一项初步研究
Ann Nucl Med. 2014 Oct;28(8):746-60. doi: 10.1007/s12149-014-0869-y. Epub 2014 Jun 21.
9
Cardiac PET/Computed Tomography Applications and Cardiovascular Outcome.心脏正电子发射断层扫描/计算机断层扫描应用与心血管结局
PET Clin. 2015 Jul;10(3):441-59. doi: 10.1016/j.cpet.2015.03.009. Epub 2015 Apr 16.
10
What is ischemia and how should this be defined based on modern imaging?什么是缺血，基于现代影像学应该如何定义？
Prog Cardiovasc Dis. 2015 May-Jun;57(6):537-54. doi: 10.1016/j.pcad.2015.02.001. Epub 2015 Feb 27.
引用本文的文献
1
Myocardial Infarction with Nonobstructive Coronary Artery Disease-Definition, Etiopathogenesis, Diagnosis, and Management.非阻塞性冠状动脉疾病所致心肌梗死——定义、病因发病机制、诊断与管理
Int J Angiol. 2021 Mar 3;33(4):211-221. doi: 10.1055/s-0041-1724040. eCollection 2024 Dec.
2
Preclinical evaluation of [F]SYN1 and [F]SYN2, novel radiotracers for PET myocardial perfusion imaging.新型正电子发射断层显像（PET）心肌灌注显像剂[F]SYN1和[F]SYN2的临床前评估
EJNMMI Res. 2024 Jul 8;14(1):63. doi: 10.1186/s13550-024-01122-5.
3
Role of Transesophageal Echocardiography in the Diagnosis of Coronary Ischemia in a Patient with History of Ross Procedure.经食管超声心动图在有Ross手术史患者冠状动脉缺血诊断中的作用
CASE (Phila). 2024 Mar 8;8(3Part A):109-116. doi: 10.1016/j.case.2023.12.021. eCollection 2024 Mar.
4
Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.心血管疾病研究中使用动物模型和正电子发射断层扫描放射性示踪剂的最新进展。
Int J Mol Sci. 2022 Dec 26;24(1):353. doi: 10.3390/ijms24010353.
5
Multimodality Imaging in Ischemic Chronic Cardiomyopathy.缺血性慢性心肌病的多模态成像
J Imaging. 2022 Feb 1;8(2):35. doi: 10.3390/jimaging8020035.
6
Ischemic Heart Disease: Noninvasive Imaging Techniques and Findings.缺血性心脏病：无创影像学技术与表现。
Radiographics. 2021 Jul-Aug;41(4):990-1021. doi: 10.1148/rg.2021200125. Epub 2021 May 21.
7
H3K14 hyperacetylation‑mediated c‑Myc binding to the miR‑30a‑5p gene promoter under hypoxia postconditioning protects senescent cardiomyocytes from hypoxia/reoxygenation injury.低氧后处理通过组蛋白 H3K14 乙酰化介导 c-Myc 与 miR-30a-5p 基因启动子结合，保护衰老心肌细胞免受低氧/复氧损伤。
Mol Med Rep. 2021 Jun;23(6). doi: 10.3892/mmr.2021.12107. Epub 2021 Apr 21.
8
Intensive care unit management of percutaneous mechanical circulatory supported patients: the role of imaging.经皮机械循环支持患者的重症监护病房管理：影像学的作用。
Eur Heart J Suppl. 2021 Mar 27;23(Suppl A):A15-A22. doi: 10.1093/eurheartj/suab003. eCollection 2021 Mar.
本文引用的文献
1
Imaging of chemokine receptor CXCR4 expression in culprit and nonculprit coronary atherosclerotic plaque using motion-corrected [Ga]pentixafor PET/CT.采用运动校正[Ga]戊曲肽 PET/CT 成像检测罪犯和非罪犯冠状动脉粥样硬化斑块中趋化因子受体 CXCR4 的表达。
Eur J Nucl Med Mol Imaging. 2018 Oct;45(11):1934-1944. doi: 10.1007/s00259-018-4076-2. Epub 2018 Jul 3.
2
PET Assessment of Epicardial Intimal Disease and Microvascular Dysfunction in Cardiac Allograft Vasculopathy.心脏移植血管病中外膜内膜疾病和微血管功能障碍的 PET 评估。
J Am Coll Cardiol. 2018 Apr 3;71(13):1444-1456. doi: 10.1016/j.jacc.2018.01.062.
3
Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.使用正电子发射断层扫描（PET）对心肌血流进行临床定量：SNMMI心血管委员会和ASNC的联合立场文件
J Nucl Cardiol. 2018 Feb;25(1):269-297. doi: 10.1007/s12350-017-1110-x.
4
Deaths: Final Data for 2015.死亡：2015年最终数据。
Natl Vital Stat Rep. 2017 Nov;66(6):1-75.
5
Comparison of Coronary CT Angiography, SPECT, PET, and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve.冠状动脉 CT 血管造影、SPECT、PET 和混合成像在以血流储备分数确定的缺血性心脏病诊断中的比较。
JAMA Cardiol. 2017 Oct 1;2(10):1100-1107. doi: 10.1001/jamacardio.2017.2471.
6
Prognostic Value of Coronary CT Angiography With Selective PET Perfusion Imaging in Coronary Artery Disease.冠状动脉 CT 血管造影联合选择性 PET 灌注成像对冠状动脉疾病的预后价值。
JACC Cardiovasc Imaging. 2017 Nov;10(11):1361-1370. doi: 10.1016/j.jcmg.2016.10.025. Epub 2017 May 17.
7
Detection of Atherosclerotic Inflammation by Ga-DOTATATE PET Compared to [F]FDG PET Imaging.与[F]FDG PET成像相比，用镓- DOTATATE PET检测动脉粥样硬化炎症
J Am Coll Cardiol. 2017 Apr 11;69(14):1774-1791. doi: 10.1016/j.jacc.2017.01.060.
8
Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease.因冠状动脉造影而接受检查的女性相对于男性存在额外的心血管风险，这与严重受损的冠状动脉血流储备有关，而非阻塞性疾病。
Circulation. 2017 Feb 7;135(6):566-577. doi: 10.1161/CIRCULATIONAHA.116.023266. Epub 2016 Nov 14.
9
American Society of Nuclear Cardiology and Society of Nuclear Medicine and Molecular Imaging Joint Position Statement on the Clinical Indications for Myocardial Perfusion PET.美国核心脏病学会与核医学与分子影像学会关于心肌灌注正电子发射断层显像临床适应症的联合立场声明。
J Nucl Med. 2016 Oct;57(10):1654-1656. doi: 10.2967/jnumed.116.180448. Epub 2016 Aug 25.
10
Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome.通过同时进行正电子发射断层扫描/磁共振成像对缺血后心肌中18F-氟脱氧葡萄糖摄取进行前瞻性评估，作为功能转归的预后标志物。
Circ Cardiovasc Imaging. 2016 Apr;9(4):e004316. doi: 10.1161/CIRCIMAGING.115.004316.
Zotero 插件