Chen Kevin, Miller Edward J, Sadeghi Mehran M
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA.
PET Clin. 2019 Apr;14(2):211-221. doi: 10.1016/j.cpet.2018.12.003. Epub 2019 Feb 1.
PET-based cardiac nuclear imaging plays a large role in the management of ischemic heart disease. Compared with conventional single-photon emission CT myocardial perfusion imaging, PET provides superior accuracy in diagnosis of coronary artery disease and, with the incorporation of myocardial blood flow and coronary flow reserve, adds value in assessing prognosis for established coronary and microvascular disease. This review describes these and other uses of PET in ischemic heart disease, including assessing myocardial viability in ischemic cardiomyopathy. Developments in novel PET flow tracers and molecular imaging tools to assess atherosclerotic plaque vulnerability, vascular calcification, and vascular remodeling also are described.
基于正电子发射断层扫描（PET）的心脏核成像在缺血性心脏病的管理中发挥着重要作用。与传统的单光子发射计算机断层扫描心肌灌注成像相比，PET在冠状动脉疾病的诊断中具有更高的准确性，并且通过结合心肌血流和冠状动脉血流储备，在评估已确诊的冠状动脉和微血管疾病的预后方面具有附加价值。本综述描述了PET在缺血性心脏病中的这些及其他用途，包括评估缺血性心肌病中的心肌存活情况。还介绍了新型PET血流示踪剂以及用于评估动脉粥样硬化斑块易损性、血管钙化和血管重塑的分子成像工具的进展。
