Montanaro Lucio, Testoni Francesca, Poggi Alessandro, Visai Livia, Speziale Pietro, Arciola Carla Renata
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy.
Int J Artif Organs. 2011 Sep;34(9):781-8. doi: 10.5301/ijao.5000052.
Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not. Bone is an optimal substratum for S. aureus, since this bacterium expresses various adhesins by which can adhere to bone proteins and to the biomaterial surfaces coated with the proteins of the host extracellular matrix. S. aureus is able not only to colonize bone tissues, but also to invade and disrupt them by entering bone cells and inducing cell death and osteolysis. Here we illustrate the pathogenetic mechanisms that can explain how the osteomyelitis sets in and develops around an implant.
植入物相关骨髓炎是一种严重的深部骨感染，发生并发展于植入物周围。金黄色葡萄球菌是骨髓炎的首要病因，无论是否与植入物相关。骨骼是金黄色葡萄球菌的理想生存基质，因为这种细菌表达多种粘附素，可借此粘附于骨蛋白以及涂覆有宿主细胞外基质蛋白的生物材料表面。金黄色葡萄球菌不仅能够在骨组织中定植，还能通过进入骨细胞、诱导细胞死亡和骨溶解来侵袭和破坏骨组织。在此，我们阐述了一些发病机制，这些机制可以解释植入物周围骨髓炎的发病过程和发展情况。
