Sendi Parham, Zimmerli Werner
Unit of Infectious Diseases, Basel University Medical Clinic, Liestal, Switzerland.
Int J Artif Organs. 2011 Sep;34(9):947-56. doi: 10.5301/ijao.5000032.
The number of knee arthroplasty procedures is growing and projected to further increase. The risk for periprosthetic joint infection (PJI) is estimated to be low (<1%). However, considering the increasing number of total knee arthroplasty, the increasing number of patients with multiple comorbidities, and the lifelong risk for acquiring hematogenous infection, the total number of PJI will further increase. Despite existing treatment concepts for PJI of the knee, there are still questions to solve, such as type of debridement surgery in case of implant retention, the role of a spacer from a microbiological perspective, and the optimal duration of antimicrobial therapy. In this REVIEW, these questions will be analyzed according to the available literature and the experience of the authors. Moreover, we REVIEW the most recent data on infection, risk factors, and microbiology of PJI.
膝关节置换手术的数量正在增加，并且预计还会进一步上升。人工关节周围感染（PJI）的风险估计较低（<1%）。然而，考虑到全膝关节置换数量的增加、合并多种疾病患者数量的增多以及发生血源性感染的终身风险，PJI的总数将会进一步增加。尽管目前存在针对膝关节PJI的治疗理念，但仍有一些问题有待解决，例如在保留植入物的情况下清创手术的类型、从微生物学角度看间隔物的作用以及抗菌治疗的最佳持续时间。在本综述中，将根据现有文献和作者的经验对这些问题进行分析。此外，我们还综述了有关PJI的感染、危险因素和微生物学的最新数据。
