Kamerling S G, Hamra J G, Bagwell C A
Department of Veterinary Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Baton Rouge, Louisiana 70803-8422.
Equine Vet J. 1990 Jul;22(4):241-3. doi: 10.1111/j.2042-3306.1990.tb04260.x.
Endogenous opioid peptides have been implicated in the regulation of pain perception, behaviour, gastrointestinal activity and other physiological responses. However, the functional role of these peptides in the horse has yet to be elucidated. The opioid antagonist, naloxone, is often administered to infer endogenous opioid effects. In the present study, naloxone (0.75 mg/kg bodyweight) was administered to eight Thoroughbred racehorses and a number of behavioural and autonomic responses were measured. Naloxone produced rapid onset diarrhoea, restlessness, abdominal checking, tachycardia, tachypnoea, paradoxical yawning and diaphoresis. These responses described an acute abdominal distress syndrome similar to spasmodic colic. Results from this study suggest that, in the horse, endogenous opioids: 1) influence behaviour, 2) modify intestinal activity and sensation, and 3) if perturbed, may be involved in pathophysiology of colic.
内源性阿片肽与疼痛感知、行为、胃肠活动及其他生理反应的调节有关。然而，这些肽在马体内的功能作用尚未阐明。阿片拮抗剂纳洛酮常被用于推断内源性阿片效应。在本研究中，对八匹纯种赛马注射了纳洛酮（0.75毫克/千克体重），并测量了一些行为和自主反应。纳洛酮引发了快速腹泻、烦躁不安、腹部检查、心动过速、呼吸急促、反常呵欠和出汗。这些反应描述了一种类似于痉挛性绞痛的急性腹部窘迫综合征。本研究结果表明，在马体内，内源性阿片肽：1）影响行为，2）改变肠道活动和感觉，3）若受到干扰，可能参与绞痛的病理生理学过程。
