Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Str. 2, D-48149 Münster, Germany.
Chem Commun (Camb). 2012 Jan 7;48(2):296-8. doi: 10.1039/c1cc15834a. Epub 2011 Nov 18.
A new route to the synthesis of triazole-linked ubiquitin dimers (diUbs) as structural analogs of the seven diUbs is reported. Binding studies with the Lys48-specific UBA domain of the Mud1 protein suggest that they represent functionally suitable surrogates of their native counterparts linked by an isopeptide bond.
报道了一种合成三唑连接的泛素二聚体（diUbs）的新途径，作为七聚体的结构类似物。与 Mud1 蛋白的 Lys48 特异性 UBA 结构域的结合研究表明，它们代表了功能上合适的替代物，通过异肽键连接。
