泛素的化学生物学。
The chemical biology of ubiquitin.
机构信息
Department of Biochemistry and Biophysics, Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
出版信息
Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130079. doi: 10.1016/j.bbagen.2021.130079. Epub 2021 Dec 29.
Abstract
This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biological systems as well as the hijacking of the ubiquitin proteasome system using heterobifunctional compounds to induce intracellular ubiquitination.
摘要
这篇小型综述将涵盖用于制备和调节泛素链和泛素-蛋白酶体系统的各种化学生物学方法。重点将放在多泛素链制备的生物化学和化学生物学上，作为阐明其在生物系统中的作用的工具，以及使用杂双功能化合物劫持泛素蛋白酶体系统以诱导细胞内泛素化。
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