Zhao Hong, Wang Jian, Han Yongqing, Huang Zhen, Ying Jianming, Bi Xinyu, Zhao Jianjun, Fang Yi, Zhou Haitao, Zhou Jianguo, Li Zhiyu, Zhang Yefan, Yang Xue, Yan Tao, Wang Linfang, Torbenson Michael S, Cai Jianqiang
Department of abdominal surgical oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China.
Oncotarget. 2011 Nov;2(11):886-91. doi: 10.18632/oncotarget.355.
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.
肝细胞癌（HCC）是全球最常见的恶性肿瘤之一，然而，与HCC发生相关的基因-环境相互作用及其机制仍不清楚。我们最近的研究通过对10例丙型肝炎病毒（HCV）相关HCC进行外显子组测序，并对其他受影响个体的肿瘤进行后续评估，描述了HCC四种主要亚型中ARID2（富含AT交互结构域2）的新型失活突变。在此，我们总结了目前关于ARID2在HCC中的相关性及其对未来患者护理的意义的认识。
