Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Macromol Rapid Commun. 2011 Dec 15;32(24):1979-85. doi: 10.1002/marc.201100493. Epub 2011 Nov 18.
Nanoparticles consisting of a photoreactive polymer able to radically switch its hydrophobicity are successfully prepared by miniemulsion polymerization. Irradiation with UV light causes degradation of the particles where at complete dissolution is achieved by changing the initial hydrophobic photoresist polymer into hydrophilic poly(methacrylic acid). Incorporation of the fluorescence-sensitive Nile red serves as a solvatochromic probe to study the particle degradation. Diffusion of either Nile red out from or water into the former hard spherical nanoparticles is studied and not only renders the described material an ideal system for applications, where in situ dissolution of nanoparticles may be needed, but also bears the additional advantage of performing controlled burst release.
通过细乳液聚合成功制备了由光反应性聚合物组成的纳米粒子，该聚合物能够彻底改变其疏水性。用紫外光照射会导致颗粒降解，通过将初始的疏水光致聚合物转变为亲水性聚（甲基丙烯酸），可实现完全溶解。荧光敏感尼罗红的掺入作为溶剂变色探针来研究颗粒降解。研究了尼罗红从纳米粒子中扩散出来或水进入纳米粒子的扩散情况，这不仅使所描述的材料成为需要原位溶解纳米粒子的应用的理想体系，而且还具有进行控制式爆发释放的额外优势。
