Wassie E, Abdulkadir J
Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Ethiopia.
Ethiop Med J. 1990 Jul;28(3):139-43.
Thyroid function values were determined in 56 healthy nongoitrous adult Ethiopians. The mean triiodothyronine (T3) values for 20 males and 36 females were 1.42 +/- 0.32 nmol/L and 1.51 +/- 0.25 nmol/L, and thyroxine (T4) values were 119 22 nmol/L and 116 +/- 21 nmol/L respectively. The mean thyrotropin (TSH) values for males and females were identical at 1.85 +/- 0.94 mu/L. Radioactive iodine uptake (RAIU) at 2 hours was 8.6 +/- 4.4% in males and 11.3 +/- 4.3% in females, and at 24 hours 31.7 +/- 11.7% and 38.9 +/- 11.1% respectively. The differences between males and females were significant at both 2 and 24 hours (P less than 0.05). The ranges for the 3 hormones derived from the mean 2SD values are close to those supplied with the kits but the Ethiopian RAIU values are higher than the values currently applicable in developed countries, probably indicative of the lower level of dietary iodine available to the population here. The values obtained in this study are offered to serve as normal reference for the interpretation of thyroid function results in Ethiopian patients. A strategy for the rational utilization of the available in vivo [corrected] tests is suggested.
对56名健康无甲状腺肿的成年埃塞俄比亚人测定了甲状腺功能值。20名男性和36名女性的平均三碘甲状腺原氨酸（T3）值分别为1.42±0.32nmol/L和1.51±0.25nmol/L，甲状腺素（T4）值分别为119±22nmol/L和116±21nmol/L。男性和女性的平均促甲状腺激素（TSH）值相同，为1.85±0.94μ/L。男性2小时放射性碘摄取（RAIU）为8.6±4.4%，女性为11.3±4.3%；24小时分别为31.7±11.7%和38.9±11.1%。男性和女性在2小时和24小时时的差异均具有统计学意义（P<0.05）。根据平均±2标准差得出的三种激素的范围与试剂盒提供的范围接近，但埃塞俄比亚的RAIU值高于目前发达国家适用的值，这可能表明当地人群饮食中碘的可利用水平较低。本研究获得的值可作为解释埃塞俄比亚患者甲状腺功能结果的正常参考。建议了一种合理利用现有体内[校正后]检测方法的策略。
