Huong D T M, Bannister W, Phong P T, Kirk O, Peters L
Viet Tiep Hospital, Haiphong, Vietnam.
Int J STD AIDS. 2011 Nov;22(11):659-64. doi: 10.1258/ijsa.2011.010515.
The objective of our study was to investigate factors associated with virological failure in 100 consecutive HIV-1 infected Vietnamese adults who initiated antiretroviral therapy (ART) from June 2007 to June 2008. Data were collected from medical records, and a structured questionnaire was used in individual interviews to investigate factors associated with adherence to ART. Plasma HIV viral load was measured at the time of the interview. The median age was 35 years, 35% were women and heterosexual intercourse was the most common mode of HIV transmission (61%). After a median of 14 months since starting ART, 23% had detectable HIV-1 viral load (≥ 400 copies/mL). Patients who had developed a World Health Organization (WHO) clinical stage 4 condition at the time of initiation of ART were more likely to experience virological failure than those in stages 1-3, odds ratio (OR): 5.20 (95% confidence interval [CI] 1.34-20.11), P = 0.017. Patients who reported that their health status was evaluated by a physician at each visit were less likely to experience virological failure, OR: 0.02 (95% CI 0.00-0.24), P = 0.002.
我们研究的目的是调查2007年6月至2008年6月期间开始接受抗逆转录病毒治疗（ART）的100名连续的HIV-1感染越南成年人中与病毒学失败相关的因素。数据从医疗记录中收集，并在个人访谈中使用结构化问卷来调查与ART依从性相关的因素。在访谈时测量血浆HIV病毒载量。中位年龄为35岁，35%为女性，异性性行为是最常见的HIV传播方式（61%）。开始ART后中位14个月时，23%的患者HIV-1病毒载量可检测到（≥400拷贝/毫升）。在开始ART时已发展为世界卫生组织（WHO）临床4期疾病的患者比1-3期患者更有可能经历病毒学失败，比值比（OR）：5.20（95%置信区间[CI]1.34-20.11），P = 0.017。报告每次就诊时医生都对其健康状况进行评估的患者经历病毒学失败的可能性较小，OR：0.02（95%CI 0.00-0.24），P = 0.002。
