脑磷脂酰肌醇磷酸二酯酶对脂肪酸刺激的膜磷脂酰肌醇水解作用。
Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.
作者信息
Irvine R F, Letcher A J, Dawson R M
出版信息
Biochem J. 1979 Feb 15;178(2):497-500. doi: 10.1042/bj1780497.
Abstract
The hydrolysis of membrane-bound phosphatidylinositol in rat liver microsomal fraction by the soluble phosphatidylinositol phosphodiesterase from rat brain was markedly stimulated by oleic acid or arachidonic acid. The stimulation did not require added calcium, although it was abolished by EDTA. Lysophosphatidylcholine also totally suppressed the stimulation. A possible role for the fatty acid content of a membrane in controlling phosphatidylinositol turnover is suggested.
摘要
大鼠脑中可溶性磷脂酰肌醇磷酸二酯酶对大鼠肝微粒体部分中膜结合磷脂酰肌醇的水解作用，可被油酸或花生四烯酸显著增强。这种增强作用不需要额外添加钙，不过会被乙二胺四乙酸（EDTA）消除。溶血磷脂酰胆碱也能完全抑制这种增强作用。由此表明，膜的脂肪酸含量在控制磷脂酰肌醇周转方面可能发挥作用。
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