肌醇磷酸酯对豚鼠肝细胞中钙离子池的作用。
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes.
作者信息
Burgess G M, Irvine R F, Berridge M J, McKinney J S, Putney J W
出版信息
Biochem J. 1984 Dec 15;224(3):741-6. doi: 10.1042/bj2240741.
Abstract
In permeabilized hepatocytes, inositol 1,4,5-trisphosphate, inositol 2,4,5-trisphosphate and inositol 4,5-bisphosphate induced rapid release of Ca2+ from an ATP-dependent, non-mitochondrial vesicular pool, probably endoplasmic reticulum. The order of potency was inositol 1,4,5-trisphosphate greater than inositol 2,4,5-trisphosphate greater than inositol 4,5-bisphosphate. The Ca2+-releasing action of inositol 1,4,5-trisphosphate is not inhibited by high [Ca2+], nor is it dependent on [ATP] in the range of 50 microM-1.5 mM. These results suggest a role for inositol 1,4,5-trisphosphate as a second messenger in hormone-induced Ca2+ mobilisation, and that a specific receptor is involved in the Ca2+-release mechanism.
摘要
在通透的肝细胞中，肌醇1,4,5-三磷酸、肌醇2,4,5-三磷酸和肌醇4,5-二磷酸可诱导Ca2+从一个依赖ATP的非线粒体囊泡池（可能是内质网）快速释放。其效力顺序为肌醇1,4,5-三磷酸大于肌醇2,4,5-三磷酸大于肌醇4,5-二磷酸。肌醇1,4,5-三磷酸的Ca2+释放作用不受高[Ca2+]抑制，在50微摩尔/升至1.5毫摩尔/升范围内也不依赖于[ATP]。这些结果表明肌醇1,4,5-三磷酸作为激素诱导的Ca2+动员中的第二信使发挥作用，且Ca2+释放机制涉及一种特异性受体。
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