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1
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes.肌醇磷酸酯对豚鼠肝细胞中钙离子池的作用。
Biochem J. 1984 Dec 15;224(3):741-6. doi: 10.1042/bj2240741.
2
Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes.豚鼠肝细胞中对肌醇1,4,5 -三磷酸敏感的钙池大小
Biochem J. 1985 Dec 1;232(2):435-8. doi: 10.1042/bj2320435.
3
The second messenger linking receptor activation to internal Ca release in liver.将受体激活与肝脏内部钙释放相联系的第二信使。
Nature. 1984;309(5963):63-6. doi: 10.1038/309063a0.
4
Roles of Ca2+ on the inositol 1,4,5-trisphosphate-induced release of Ca2+ from saponin-permeabilized single cells of the porcine coronary artery.钙离子对猪冠状动脉皂素通透单细胞中肌醇1,4,5 -三磷酸诱导的钙离子释放的作用。
Comp Biochem Physiol A Comp Physiol. 1985;82(3):645-9. doi: 10.1016/0300-9629(85)90446-3.
5
The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization.洋地黄皂苷通透化处理的胰岛模型。肌醇1,4,5-三磷酸对钙离子动员的影响。
Biochem J. 1985 May 1;227(3):965-9. doi: 10.1042/bj2270965.
6
Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.用肌醇1,4,5 -三磷酸处理皂素处理的腹膜巨噬细胞后，Ca2+从非线粒体储存位点释放。
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7
Stimulatory effect of glucose 6-phosphate on the non-mitochondrial Ca2+ uptake in permeabilized hepatocytes and Ca2+ release by inositol trisphosphate.
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8
Inositol 1,4,5-triphosphate induces calcium release from a non- mitochondrial pool in amoebae of Dictyostelium.
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myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.肌醇1,4,5-三磷酸。肝脏中激素动员细胞内钙离子的第二信使。
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Increase in Ca2+ permeability of intracellular Ca2+ store membrane of saponin-treated guinea pig peritoneal macrophages by inositol 1,4,5-trisphosphate.1,4,5-三磷酸肌醇对皂角苷处理的豚鼠腹腔巨噬细胞细胞内钙库膜钙离子通透性的影响
J Biochem. 1985 Jun;97(6):1575-82. doi: 10.1093/oxfordjournals.jbchem.a135214.

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1
Pharmacological modulation of intracellular Ca(2+) channels at the single-channel level.单通道水平下细胞内钙离子通道的药理学调控
Mol Neurobiol. 2001 Aug-Dec;24(1-3):65-86. doi: 10.1385/MN:24:1-3:065.
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Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.哺乳动物肌醇多磷酸多激酶可合成肌醇1,4,5 -三磷酸和一种肌醇焦磷酸。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2306-11. doi: 10.1073/pnas.041614598. Epub 2001 Feb 13.
3
Regulation of Ca2+ release by InsP3 in single guinea pig hepatocytes and rat Purkinje neurons.豚鼠单个肝细胞和大鼠浦肯野神经元中肌醇三磷酸（InsP3）对钙离子释放的调节
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Autoradiographic characterization of [3H]inositol (1,4,5) trisphosphate and [3H]inositol (1,3,4,5) tetrakisphosphate binding sites in human brain.人脑 [3H] 肌醇（1,4,5）三磷酸和 [3H] 肌醇（1,3,4,5）四磷酸结合位点的放射自显影特征
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Evidence for a Ca2+ pool associated with secretory granules in rat submandibular acinar cells.大鼠下颌下腺腺泡细胞中与分泌颗粒相关的钙池的证据。
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Activation of the plasma membrane chloride channel by protein kinase C in isolated guinea-pig hepatocytes.蛋白激酶C对豚鼠离体肝细胞质膜氯通道的激活作用。
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7
Inositol 1,4,5-trisphosphate mediates adrenaline activation of K+ conductance in mouse peritoneal macrophages.肌醇1,4,5-三磷酸介导肾上腺素对小鼠腹腔巨噬细胞钾离子通道的激活作用。
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8
Kinetics of cytosolic Ca2+ concentration after photolytic release of 1-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate from a caged derivative in guinea pig hepatocytes.豚鼠肝细胞中笼形衍生物1-D-肌醇1,4-二磷酸5-硫代磷酸酯光解释放后胞质Ca2+浓度的动力学
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9
Calcium and inositol trisphosphate receptors.
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10
Caffeine inhibits cytosolic calcium oscillations induced by noradrenaline and vasopressin in rat hepatocytes.咖啡因可抑制去甲肾上腺素和血管加压素在大鼠肝细胞中诱导的胞质钙振荡。
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本文引用的文献

1
Complete characterization of the myo-inositol polyphosphates from beef brain phosphoinositide.牛肉脑磷脂酰肌醇中肌醇多磷酸的完整表征。
J Biol Chem. 1961 Jul;236:1902-6.
2
Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.通过牛肉脑磷酸肌醇碱性水解得到的肌醇磷酸酯。
J Biol Chem. 1961 Jan;236:54-60.
3
Role of calcium in the hormonal regulation of liver metabolism.钙在肝脏代谢激素调节中的作用。
Biochim Biophys Acta. 1981 Dec 30;639(3-4):243-95. doi: 10.1016/0304-4173(81)90012-4.
4
Calcium uptake into acini from rat pancreas: evidence for intracellular ATP-dependent calcium sequestration.大鼠胰腺腺泡对钙的摄取：细胞内ATP依赖的钙螯合的证据。
J Membr Biol. 1982;65(3):205-20. doi: 10.1007/BF01869964.
5
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.肌醇1,4,5-三磷酸。肝脏中激素动员细胞内钙离子的第二信使。
J Biol Chem. 1984 Mar 10;259(5):3077-81.
6
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
Nature. 1983;306(5938):67-9. doi: 10.1038/306067a0.
7
Alpha-adrenergic stimulation of potassium efflux in guinea-pig hepatocytes may involve calcium influx and calcium release.豚鼠肝细胞中α-肾上腺素能刺激钾外流可能涉及钙内流和钙释放。
J Physiol. 1984 Jan;346:395-407. doi: 10.1113/jphysiol.1984.sp015030.
8
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells.三磷酸肌醇诱导通透化的瑞士小鼠3T3细胞释放钙的特异性
Biochem J. 1984 Aug 15;222(1):269-72. doi: 10.1042/bj2220269.
9
The second messenger linking receptor activation to internal Ca release in liver.将受体激活与肝脏内部钙释放相联系的第二信使。
Nature. 1984;309(5963):63-6. doi: 10.1038/309063a0.
10
Metabolism of inositol phosphates in parotid cells: implications for the pathway of the phosphoinositide effect and for the possible messenger role of inositol trisphosphate.腮腺细胞中肌醇磷酸的代谢：对磷酸肌醇效应途径及肌醇三磷酸可能的信使作用的影响。
Life Sci. 1984 Apr 2;34(14):1347-55. doi: 10.1016/0024-3205(84)90006-7.

肌醇磷酸酯对豚鼠肝细胞中钙离子池的作用。

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes.

作者信息

Burgess G M, Irvine R F, Berridge M J, McKinney J S, Putney J W

出版信息

Biochem J. 1984 Dec 15;224(3):741-6. doi: 10.1042/bj2240741.

DOI:10.1042/bj2240741
PMID:6525174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144508/
Abstract

In permeabilized hepatocytes, inositol 1,4,5-trisphosphate, inositol 2,4,5-trisphosphate and inositol 4,5-bisphosphate induced rapid release of Ca2+ from an ATP-dependent, non-mitochondrial vesicular pool, probably endoplasmic reticulum. The order of potency was inositol 1,4,5-trisphosphate greater than inositol 2,4,5-trisphosphate greater than inositol 4,5-bisphosphate. The Ca2+-releasing action of inositol 1,4,5-trisphosphate is not inhibited by high [Ca2+], nor is it dependent on [ATP] in the range of 50 microM-1.5 mM. These results suggest a role for inositol 1,4,5-trisphosphate as a second messenger in hormone-induced Ca2+ mobilisation, and that a specific receptor is involved in the Ca2+-release mechanism.

摘要

在通透的肝细胞中，肌醇1,4,5-三磷酸、肌醇2,4,5-三磷酸和肌醇4,5-二磷酸可诱导Ca2+从一个依赖ATP的非线粒体囊泡池（可能是内质网）快速释放。其效力顺序为肌醇1,4,5-三磷酸大于肌醇2,4,5-三磷酸大于肌醇4,5-二磷酸。肌醇1,4,5-三磷酸的Ca2+释放作用不受高[Ca2+]抑制，在50微摩尔/升至1.5毫摩尔/升范围内也不依赖于[ATP]。这些结果表明肌醇1,4,5-三磷酸作为激素诱导的Ca2+动员中的第二信使发挥作用，且Ca2+释放机制涉及一种特异性受体。