Zhou Wei, Yi Juan, Huang Hui-Ping, Xiang Ying-Ping, He Jia-Xi, Liu Qing-Jun, Huang Xian-Qing
Shenzhen Institute of Occupational Disease Treatment and Prevention, Shenzhen 518001, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Jun;29(6):421-3.
To explore the effects of n-hexane on expression of serum myelin proteins (MBP) in workers occupationally exposed to n-hexane.
In this study, 269 workers exposed to n-hexane for more than one year and 104 subjects not exposed to n-hexane served as the exposure group and the control group, respectively. The urinary 2,5-hexanedione levels in all subjects were detected. On the basis of urinary 2,5-hexanedione levels, the exposure group was divided into the high exposure sub-group and low exposure sub-group. The serum myelin basic protein (MBP) levels were measured by ELISA kit.
The mean concentration of urinary 2,5-hexanedione in the exposed group was (3.10 +/- 1.35) mg/L. The concentration of urinary 2,5-hexanedione in the control group was undetectable. The levels of serum MBP in the high exposure sub-group and low exposure sub-group were (2.43 +/- 0.24) and (1.62 +/- 0.23) microg/L, respectively, which were significantly higher than that (0.78 +/- 0.12) microg/L in the controls (P < 0.01). Pearson correlation analysis showed the positive correlation between serum MBP levels and urinary 2,5-hexanedione levels (r = 0.781, P < 0.01).
The results of present study showed that the serum MBP levels of workers occupationally exposed to n-hexane significantly elevated, and the serum MBP can serve as the effective biomarker of n-hexane exposure.
探讨正己烷对职业接触正己烷工人血清髓鞘蛋白（MBP）表达的影响。
本研究中，将269名接触正己烷一年以上的工人和104名未接触正己烷的受试者分别作为暴露组和对照组。检测所有受试者尿中2,5-己二酮水平。根据尿中2,5-己二酮水平，将暴露组分为高暴露亚组和低暴露亚组。采用ELISA试剂盒测定血清髓鞘碱性蛋白（MBP）水平。
暴露组尿中2,5-己二酮平均浓度为（3.10±1.35）mg/L。对照组尿中2,5-己二酮浓度未检出。高暴露亚组和低暴露亚组血清MBP水平分别为（2.43±0.24）和（1.62±0.23）μg/L，显著高于对照组的（0.78±0.12）μg/L（P<0.01）。Pearson相关分析显示血清MBP水平与尿中2,5-己二酮水平呈正相关（r=0.781，P<0.01）。
本研究结果表明，职业接触正己烷工人的血清MBP水平显著升高，血清MBP可作为正己烷暴露的有效生物标志物。
