Paz Ziv, Nails Michael, Ziv Elad
Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
Isr Med Assoc J. 2011 Oct;13(10):625-9.
In Israel, Yemenite Jews and other populations including Ethiopian Jews and Bedouins have a low neutrophil count. This phenomenon has been called "benign neutropenia" since it has not been associated with any increased risk of infection and has also been described in other populations around the world including Africans, African Americans and Afro-Carribeans. Here we describe the recent success in mapping the gene that underlies benign neutropenia in African American populations. We discuss the known function of the gene and consider potential mechanisms for the effect on neutropenia. We also consider the possibility that this gene underlies the same effect observed in Yemenite Jews, Ethiopian Jews and Bedouins in Israel.
在以色列，也门犹太人以及包括埃塞俄比亚犹太人、贝都因人在内的其他人群中性粒细胞计数较低。这一现象被称为“良性中性粒细胞减少症”，因为它与感染风险增加并无关联，并且在世界其他人群中也有描述，包括非洲人、非裔美国人和非裔加勒比人。在此，我们描述了近期在定位非裔美国人群中良性中性粒细胞减少症相关基因方面所取得的成功。我们讨论了该基因的已知功能，并思考了其影响中性粒细胞减少症的潜在机制。我们还考虑了该基因是否是导致在以色列的也门犹太人、埃塞俄比亚犹太人和贝都因人中观察到的相同效应的原因。
