[三角叶风毛菊中的类异戊二烯和苯丙烷类化合物]

[Isoprenoids and phenylpropanoids from Saussurea deltoidea].

作者信息

Huang Huoqiang, Yan Meina, Piao Xianglan

机构信息

Key Lab of Chinese Minority Traditional Medicine, Ministry of Education, Academe of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(16):2211-4.

PMID:22097332

Abstract

To investigate the chemical constituents of Saussurea deltoidea, 10 compounds were isolated from the title plant by various chromatography methods such as silica gel, RP-18 silica gel, Sephadex LH-20 column chromatography, HPLC, et al. Their structures were elucidated by spectral analysis. Five isoprenoids and Five phenylpropanoids were isolated and elucidated as (3R, 6R, 7E) -3-hydroxy-4, 7-megastigmadien-9-one (1), (3S, 5R, 6S, 7E) -5, 6-epoxy-3-hydroxy-7-megastigmen-9-one (2), 3-hydroxy-beta-damascone (3), S-(+) -dehydrovomifoliol (4), megastigman-5-ene-3beta, 9R-diol (5), coniferaldehyde (6), beta-hydroxypropiovanillone (7), 3-hydroxy-1-(4-hydroxy-3, 5-dimethoxyphenyl) -1-propanone (8), dihydrosyringenin (9), 4-[(1S) -3-hydroxy-1-methoxypropyl]-2, 6-dimenthoxyphenol (10). All the compounds were isolated from S. deltoidea for the first time.

摘要

为研究三角叶风毛菊的化学成分，通过硅胶、RP - 18硅胶、葡聚糖凝胶LH - 20柱色谱、高效液相色谱等多种色谱方法从该植物中分离得到10个化合物。通过光谱分析确定了它们的结构。分离并鉴定出5个类异戊二烯和5个苯丙素类化合物，分别为(3R, 6R, 7E) - 3 - 羟基 - 4, 7 - 大柱香波龙二烯 - 9 - 酮(1)、(3S, 5R, 6S, 7E) - 5, 6 - 环氧 - 3 - 羟基 - 7 - 大柱香波龙 - 9 - 酮(2)、3 - 羟基 - β - 大马酮(3)、S - (+) - 脱氢催吐萝芙木醇(4)、大柱香波龙 - 5 - 烯 - 3β, 9R - 二醇(5)、松柏醛(6)、β - 羟基苯丙酮(7)、3 - 羟基 - 1 - (4 - 羟基 - 3, 5 - 二甲氧基苯基) - 1 - 丙酮(8)、二氢丁香素(9)、4 - [(1S) - 3 - 羟基 - 1 - 甲氧基丙基] - 2, 6 - 二甲氧基苯酚(10)。所有化合物均首次从三角叶风毛菊中分离得到。