Li Yinchao, Huang Lanlan, Zhao Yihong, Wang Caifang, Li Raorao, Gu Yan, Liu Xuewu, Huang Luqi, Wang Suihua
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(16):2250-4.
To investigate the effects of refining temperatures and amounts of sheep's oil used in processing Epimedii Folium on Kedney-yang deficiency rats.
The corticosterone was subcutaneous injected to establish the kidney yang deficiency rat model. With the temperatures and amounts of sheep's oil were 250 degrees C/30%, 120 degrees C/30% and 120 degrees C/20% respectively, the crude drug and three kinds of pressed Epimedii Folium were extracted by water and used as examined samples while total flavonoid of Epimedii Folium was used as positive control. After examined samples and control samples were intragastirc administrated, the pharmacologic action was analyzed.
As compared to crude drug, all of the aqueous extracts of processed Epimedii Folium have stronger effect of warming kidney and enhancing yang, especially the Epimedii Folium processed by sheep's oil with refining temperatures 120 degrees C and amounts of sheep's oil 30%. Its mechanism might be related to improving the insufficiency of hypothalamic-pituitary-adrenal-thymus (HPAT) axis suppression.
The refining temperature of sheep's oil can affect the quality of excipients and processed drugs. The results may be useful in explaining the mechanism of Epimedii Folium processing and establishment of pharmaceutical standard of sheep's oil used as processing excipients.
考察淫羊藿炮制过程中炼羊脂温度及用量对肾阳虚大鼠的影响。
采用皮下注射皮质酮法建立肾阳虚大鼠模型。以250℃/30%、120℃/30%、120℃/20%的炼羊脂温度及用量，对淫羊藿生药及三种炮制品进行水提取，作为供试样品，以淫羊藿总黄酮为阳性对照。供试样品及对照样品灌胃给药后，分析其药理作用。
与淫羊藿生药相比，各炮制品水提取物均有较强的温肾壮阳作用，尤以120℃、30%炼羊脂用量炮制的淫羊藿作用最强。其作用机制可能与改善下丘脑-垂体-肾上腺-胸腺（HPAT）轴抑制功能不足有关。
炼羊脂温度可影响辅料及炮制品质量。该结果有助于阐释淫羊藿炮制机制及建立炼羊脂作为炮制辅料的药用标准。
