Wang Lili, He Jin, Wang Jieping
State Key Laboratory of Agricultural Microbiology and National Engineering, Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan 430070, China.
Wei Sheng Wu Xue Bao. 2011 Aug;51(8):1007-13.
The recently discovered Clustered Regularly Interspaced Short Palindromic Repeat (CRISPRs) can protect bacteria and archaea with adaptive and heritable defense systems against the invasion of phage- and plasmid- associated mobile genetic elements. Here, we review the structure, diversity, mechanism of interference and self versus non-self discrimination of CRISPR systems. We also discuss the potential applications of this novel interference system.
最近发现的成簇规律间隔短回文重复序列（CRISPRs）可以通过适应性和遗传性防御系统保护细菌和古细菌免受噬菌体和质粒相关移动遗传元件的入侵。在此，我们综述了CRISPR系统的结构、多样性、干扰机制以及自我与非自我识别。我们还讨论了这种新型干扰系统的潜在应用。
