Pache T D, Wladimiroff J W, de Jong F H, Hop W C, Fauser B C
Dijkzigt University Hospital, Rotterdam, The Netherlands.
Fertil Steril. 1990 Oct;54(4):638-42. doi: 10.1016/s0015-0282(16)53821-7.
Transvaginal ultrasound examinations were performed in seven normally cycling women to characterize growth of nondominant follicles in both ovaries. Mean follicle number showed little variation throughout the menstrual cycle with no differences between dominant and nondominant ovaries. Up to 11 follicles (greater than or equal to 2 mm) were observed in any one ovary. From observations of the first appearance of the dominant follicle (mean size 9.9 +/- 3.0 [SD] mm), selection was assumed to take place on cycle day 6.3 +/- 2.3. The diameter of nondominant follicles always remained less than 11 mm. Growth of small follicles was established in both dominant and nondominant ovaries up to the time of selection. The late follicular and luteal phases were characterized by a decrease in mean growth slopes of nondominant follicles in the dominant ovary only. These observations may provide in vivo evidence for the concept of intraovarian paracrine mechanisms and may have implications for the sonographic diagnosis of anovulation and monitoring of ovulation induction.
对7名月经周期正常的女性进行经阴道超声检查，以描述双侧卵巢中非优势卵泡的生长情况。整个月经周期中平均卵泡数量变化不大，优势卵巢和非优势卵巢之间无差异。任一卵巢中最多可观察到11个卵泡（直径大于或等于2毫米）。从优势卵泡首次出现（平均大小为9.9 +/- 3.0 [标准差]毫米）的观察结果来看，推测选择发生在月经周期的第6.3 +/- 2.3天。非优势卵泡的直径始终小于11毫米。在选择发生之前，优势卵巢和非优势卵巢中的小卵泡均有生长。仅在优势卵巢中，卵泡晚期和黄体期的特征是非优势卵泡的平均生长斜率下降。这些观察结果可能为卵巢内旁分泌机制的概念提供体内证据，并可能对无排卵的超声诊断和促排卵监测有影响。
