Watson P G, Jakeman C, Ozturk M, Barnett M F, Barnett F, Khaw K T
Addenbrookes Hospital, Cambridge, England.
Eye (Lond). 1990;4 ( Pt 3):425-38. doi: 10.1038/eye.1990.54.
The complications of trabeculectomy were studied in two groups of patients taken from a stable white population. The first group who had had their operation when it was first introduced 22 years ago, had been previously treated with prolonged medication, the second group had been operated upon recently and had had short-term pre-operative medication. This study confirmed that trabeculectomy predictably reduces the intraocular pressure to within the accepted normal range and that the pressure level below which the intraocular pressure could not be expected to fall was congruent to 14 mm/Hg. It also revealed that although some post operative abnormality was noted in two-thirds of the patients there were no long term problems which could be related to any operative or immediately post-operative complications, including shallow anterior chambers, uveitis and hyphaema. However, there was a long term reduction in the visual acuity and visual fields of about one-third of the patients, which was not related to cataract formation, macular problems, the height of the preoperative intraocular pressure, the amount by which this fell as a result of the surgery, or the amount, length or type of preoperative medication given before the operation. Although there was some increase in cataracts throughout the whole long term group this was mainly in those who had cataract prior to surgery; the increase was not related to operations or any other factor other than corneo-lenticular contact post-operatively.
在两组来自稳定白人人群的患者中研究了小梁切除术的并发症。第一组患者在22年前小梁切除术首次引入时接受了手术,此前接受了长期药物治疗;第二组患者最近接受了手术,术前仅接受了短期药物治疗。这项研究证实,小梁切除术可预期地将眼压降低到公认的正常范围内,且眼压预期不会降至的水平相当于14毫米汞柱。研究还表明,虽然三分之二的患者术后出现了一些异常情况,但没有与任何手术或术后即刻并发症相关的长期问题,包括浅前房、葡萄膜炎和前房积血。然而,约三分之一的患者视力和视野出现了长期下降,这与白内障形成、黄斑问题、术前眼压高度、手术导致的眼压下降幅度,或手术前给予的术前药物剂量、时长或类型无关。虽然在整个长期随访组中白内障有一定程度的增加,但这主要发生在术前就患有白内障的患者中;这种增加与手术或术后晶状体与角膜接触以外的任何其他因素无关。